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(R)-4-[2-(Methylsulfanyl)pyrimidin-4-yl]-1-(tetrahydrofuran-3-yl)-1H-pyrazol-5-amine
- Source :
- Acta Crystallographica Section E, Vol 65, Iss 4, Pp o697-o697 (2009), Acta Crystallographica Section E: Structure Reports
- Publication Year :
- 2009
- Publisher :
- International Union of Crystallography, 2009.
-
Abstract
- The title compound, C12H15N5OS, was obtained by reaction of 2-(2-(methylthio)pyrimidin-4-yl)-3-oxopropanenitrile with (tetrahydrofuran-3-yl)hydrazine dihydrochloride, and the racemic product was subsequently separated by chiral chromatography (first peak; [α]D20 = +51.3°). The chiral center at the substituted atom of the tetrahydrofuranyl group has an R-configuration. The pyrimidine and pyrazolyl rings are almost coplanar, their mean planes forming a dihedral angle of 6.4 (1)°. One of the H atoms of the amino group participates in an intramolecular hydrogen bond with the pyrimidine N atom in position 3. The second H atom is involved in an intermolecular hydrogen bond, which links the molecules into an infinite chain.
Details
- Language :
- English
- ISSN :
- 16005368
- Volume :
- 65
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Acta Crystallographica Section E
- Accession number :
- edsair.doi.dedup.....23e726a20d5eda5f71694410eb5da4b2