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Should Lutetium-prostate specific membrane antigen radioligand therapy for metastatic prostate cancer be used earlier in men with lymph node only metastatic prostate cancer?
- Source :
- Investigative and Clinical Urology, Investigative and Clinical Urology, Vol 62, Iss 6, Pp 650-657 (2021)
- Publication Year :
- 2021
- Publisher :
- The Korean Urological Association, 2021.
-
Abstract
- Purpose: Lutetium labelled prostate-specific membrane antigen radioligand therapy (Lu-PSMA RLT) has shown pleasing early results in management of high-volume metastatic castration resistant prostate cancer (mCRPC), but its role in the early treatment of men with only lymph node metastasis (LNM) is unknown. The aim was to assess the outcome of Lu-PSMA RLT earlier in the treatment of men with only LNM. Materials and Methods: Single institution retrospective review of men with only LNM on staging Ga-PSMA PET PSMA who proceeded with Lu-PSMA RLT. Results: There were 17 men with only LNM, including 13 with mCRPC and 3 who were both hormone and chemotherapy naïve. The median PSA was 3.7 (0.46–120 ng/mL). A PSA decline of ≥50% occurred in 10/17 (58.8%), decreasing to
- Subjects :
- Oncology
Glutamate Carboxypeptidase II
Male
medicine.medical_specialty
Urological Oncology
Urology
medicine.medical_treatment
Lymphatic metastasis
Antineoplastic Agents
Lutetium
urologic and male genital diseases
Ligands
law.invention
Time-to-Treatment
Prostate cancer
Heterocyclic Compounds, 1-Ring
Randomized controlled trial
law
Internal medicine
medicine
Glutamate carboxypeptidase II
Radioligand
Humans
Lymph node
Chemotherapy naive
Neoplasm Staging
Chemotherapy
business.industry
Prostate
Dipeptides
Middle Aged
Prostate-Specific Antigen
medicine.disease
PSMA-617
Survival Analysis
Diseases of the genitourinary system. Urology
Tumor Burden
Prostatic Neoplasms, Castration-Resistant
medicine.anatomical_structure
Treatment Outcome
Cohort
Antigens, Surface
Original Article
RC870-923
Lutetium-177
Radiopharmaceuticals
business
Subjects
Details
- Language :
- English
- ISSN :
- 2466054X and 24660493
- Volume :
- 62
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Investigative and Clinical Urology
- Accession number :
- edsair.doi.dedup.....23cf63ef344dd7d1590661c435a9c66f