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The modular serine proteases of the complement cascade
- Source :
- Current Opinion in Structural Biology, 22(3), 333. Elsevier Limited, Current Opinion in Structural Biology
- Publication Year :
- 2012
-
Abstract
- Modular serine proteases are central to the complement cascade of the mammalian humoral immune system. These proteases form protein complexes through multi-domain interactions to achieve their proteolytic activity. We review the structural insights into complement initiation by auto-activation of the hetero-tetrameric proteases of the large danger-recognition protein complexes, amplification and labelling of particles by the formation and activity of C3 convertases, and regulation by convertase dissociation and degradation to prevent ‘bystander’ damage to healthy host cells and tissues. The data reveal that complex formation and large domain–domain rearrangements underlie the proteolytic reactions of the complement cascade, which enables the host to recognize and clear invading microbes and host debris from its blood and fluids surrounding tissues.
- Subjects :
- Models, Molecular
Proteases
Protein Conformation
Complement receptor
Complement C3-C5 Convertases
Biology
Models, Biological
C5-convertase
Serine
03 medical and health sciences
0302 clinical medicine
Immune system
Structural Biology
Animals
Humans
Molecular Biology
Complement Activation
030304 developmental biology
0303 health sciences
Complement component 2
Complement System Proteins
C3-convertase
3. Good health
Complement system
Enzyme Activation
Biochemistry
Serine Proteases
030215 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0959440X
- Database :
- OpenAIRE
- Journal :
- Current Opinion in Structural Biology, 22(3), 333. Elsevier Limited, Current Opinion in Structural Biology
- Accession number :
- edsair.doi.dedup.....23c9d33b303e3feba31a3f1247c8c510