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Chronic enteropathy-related malabsorption syndrome in an adult with common variable immunodeficiency and symptomatic norovirus infection of the gut
- Source :
- BMJ Case Rep
- Publication Year :
- 2021
- Publisher :
- BMJ Publishing Group, 2021.
-
Abstract
- Common variable immunodeficiency (CVID) causes a chronic debilitating syndrome in affected patients and often leads to high morbidity and mortality. Among its several presentations, chronic enteropathy leading to malabsorption syndrome continues to offer a major diagnostic dilemma. Lately, higher testing for norovirus infection in patients with CVID enteropathy has correlated its presence to chronic diarrhoeas, severe villous atrophy and malabsorption syndromes. There have been no such reports of its clinical and histopathological manifestations in CVID from India. Here, we demonstrate the significance of testing for norovirus in the gut with multiplex PCRs in an adult patient with a chronic undiagnosed CVID enteropathy and its response to monthly intravenous immunoglobulin (IVIG) therapy. Our patient responded after three cycles of monthly IVIG with a complete clinical recovery of his bowel functions, leading to a significant improvement in his quality of life and performance status.
- Subjects :
- 0301 basic medicine
Adult
medicine.medical_specialty
Malabsorption
India
Case Report
medicine.disease_cause
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Quality of life
Malabsorption Syndromes
Internal medicine
medicine
Humans
Enteropathy
Villous atrophy
Caliciviridae Infections
Performance status
biology
business.industry
Common variable immunodeficiency
General Medicine
medicine.disease
030104 developmental biology
Common Variable Immunodeficiency
biology.protein
Norovirus
Quality of Life
030211 gastroenterology & hepatology
Antibody
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- BMJ Case Rep
- Accession number :
- edsair.doi.dedup.....23be5a6b4dd1e3cfd9ffad4013af725c