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Admission hypoxia-inducible factor 1α levels and in-hospital mortality in patients with acute decompensated heart failure
- Source :
- BMC Cardiovascular Disorders
- Publication Year :
- 2015
- Publisher :
- BioMed Central, 2015.
-
Abstract
- Background Hypoxia-inducible factor 1 (HIF-1) is a critical regulator for cellular oxygen balance. Myocardial hypoxia can induce the increased expression of HIF-1α. Our goals were to evaluate the value of HIF-1α in predicting death of patients with acute decompensated heart failure (ADHF) and describe the in vivo relationship between serum HIF-1α and N-terminal–pro-brain natriuretic peptide (NT-proBNP) levels. Method We included 296 patients who were consecutively admitted to the emergency department for ADHF. The primary end point was in-hospital death. The patients were categorized as HFrEF (patients with reduced systolic function) and HFpEF (patients with preserved systolic function) groups. Results In our patients, the median admission HIF-1α level was 2.95 ± 0.85 ng/ml. The HIF-1α level was elevated significantly in HFrEF patients and deceased patients compared with HFpEF patients and patients who survived. The HIF-1α level was positively correlated with NT-proBNP and cardiac troponin T levels, and negatively correlated with left ventricular ejection fraction and systolic blood pressure. Kaplan–Meier curves revealed a significant increase in in-hospital mortality in ADHF patients with higher HIF-1α levels. Multivariable Cox regression analysis showed that HIF-1α levels were not correlated with the short-term prognosis of ADHF patients. Conclusions This is the first study to evaluate the circulating levels of HIF-1α in ADHF patients. Serum HIF-1α levels may reflect a serious state in patients with ADHF. Due to the limitations of the study, serum HIF-1α levels were not correlated with the in-hospital mortality based on regression analysis. Further studies are needed to demonstrate the diagnostic and/or prognostic role of HIF-1α as a risk biomarker in patients with ADHF.
- Subjects :
- Male
medicine.medical_specialty
Acute decompensated heart failure
medicine.drug_class
Patient Admission
Internal medicine
medicine
Natriuretic peptide
Hypoxia-inducible factor 1α
Humans
Hospital Mortality
N-terminal–pro-brain natriuretic peptide
Angiology
Aged
Aged, 80 and over
Heart Failure
Ejection fraction
Proportional hazards model
business.industry
Middle Aged
medicine.disease
Hypoxia-Inducible Factor 1, alpha Subunit
Cardiac surgery
In-hospital mortality
Blood pressure
Heart failure
Acute Disease
Cardiology
Female
business
Cardiology and Cardiovascular Medicine
Biomarkers
Research Article
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 14712261
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- BMC Cardiovascular Disorders
- Accession number :
- edsair.doi.dedup.....2399de0e4a1bebd9b779109dadcdb014