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Lower serum 25-hydroxyvitamin D level is associated with impaired myocardial performance and left ventricle hypertrophy in newly diagnosed hypertensive patients
Lower serum 25-hydroxyvitamin D level is associated with impaired myocardial performance and left ventricle hypertrophy in newly diagnosed hypertensive patients
- Source :
- Anatolian Journal of Cardiology
- Publication Year :
- 2015
- Publisher :
- Kare Publishing, 2015.
-
Abstract
- OBJECTIVE Vitamin D deficiency is an independent risk factor for cardiovascular mortality. The relationship between vitamin D level and left ventricle (LV) myocardial performance index (MPI=Tei index), which incorporates both LV systolic function and diastolic function, was not investigated in previous studies. We hypothesized that vitamin D level may be associated with LV function and geometry. We aimed to investigate the association between serum 25-hydroxyvitamin D (25 [OH] D) levels and MPI and LV hypertrophy in hypertensive patients with newly diagnosed and preserved ejection fraction. METHODS We studied 151 sequential newly diagnosed hypertensive subjects who lived in the Cukurova region without known cardiovascular risk factors or overt heart disease (mean age: 62.8±10.4 years). Serum 25 (OH) D was measured using a direct competitive chemiluminescent immunoassay. The patients were divided into two groups according to serum 25 (OH) D level: vitamin D-non-deficient group (vitamin D≥ 20.00 ng/mL, n=53) and vitamin D-deficient group (vitamin D< 20.00 ng/mL, n=98). MPI was defined as the sum of isovolumic contraction and relaxation times divided by the ejection time. LV mass index (LVMI) was calculated by using the Devereux formula and body surface area. RESULTS MPI and LVMI values were lower and low-density lipoprotein (LDL) levels were higher in patients who were vitamin D-non-deficient than patients who were vitamin D-deficient (p
- Subjects :
- Male
Vitamin
medicine.medical_specialty
Heart disease
vitamin D deficiency
Muscle hypertrophy
chemistry.chemical_compound
Internal medicine
Vitamin D and neurology
medicine
Humans
Vitamin D
Ultrasonography
Body surface area
Ejection fraction
business.industry
Middle Aged
medicine.disease
medicine.anatomical_structure
chemistry
Ventricle
Hypertension
Cardiology
Female
Hypertrophy, Left Ventricular
Cardiology and Cardiovascular Medicine
business
Editorial Comment
Biomarkers
Subjects
Details
- ISSN :
- 21492271 and 21492263
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- The Anatolian Journal of Cardiology
- Accession number :
- edsair.doi.dedup.....238931578857971e99985a88ab1ed694
- Full Text :
- https://doi.org/10.5152/akd.2014.5637