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Lower serum 25-hydroxyvitamin D level is associated with impaired myocardial performance and left ventricle hypertrophy in newly diagnosed hypertensive patients

Lower serum 25-hydroxyvitamin D level is associated with impaired myocardial performance and left ventricle hypertrophy in newly diagnosed hypertensive patients

Authors :
Hazar Harbalıoğlu
Onur Kaypaklı
Ahmet Oytun Baykan
Omer Sen
Hakan Uçar
Mustafa Gür
Gülhan Yüksel Kalkan
Caner Türkoğlu
Betül Özaltun
Mevlüt Koç
Osman Kuloğlu
Taner Şeker
Murat Çaylı
Source :
Anatolian Journal of Cardiology
Publication Year :
2015
Publisher :
Kare Publishing, 2015.

Abstract

OBJECTIVE Vitamin D deficiency is an independent risk factor for cardiovascular mortality. The relationship between vitamin D level and left ventricle (LV) myocardial performance index (MPI=Tei index), which incorporates both LV systolic function and diastolic function, was not investigated in previous studies. We hypothesized that vitamin D level may be associated with LV function and geometry. We aimed to investigate the association between serum 25-hydroxyvitamin D (25 [OH] D) levels and MPI and LV hypertrophy in hypertensive patients with newly diagnosed and preserved ejection fraction. METHODS We studied 151 sequential newly diagnosed hypertensive subjects who lived in the Cukurova region without known cardiovascular risk factors or overt heart disease (mean age: 62.8±10.4 years). Serum 25 (OH) D was measured using a direct competitive chemiluminescent immunoassay. The patients were divided into two groups according to serum 25 (OH) D level: vitamin D-non-deficient group (vitamin D≥ 20.00 ng/mL, n=53) and vitamin D-deficient group (vitamin D< 20.00 ng/mL, n=98). MPI was defined as the sum of isovolumic contraction and relaxation times divided by the ejection time. LV mass index (LVMI) was calculated by using the Devereux formula and body surface area. RESULTS MPI and LVMI values were lower and low-density lipoprotein (LDL) levels were higher in patients who were vitamin D-non-deficient than patients who were vitamin D-deficient (p

Details

ISSN :
21492271 and 21492263
Volume :
15
Database :
OpenAIRE
Journal :
The Anatolian Journal of Cardiology
Accession number :
edsair.doi.dedup.....238931578857971e99985a88ab1ed694
Full Text :
https://doi.org/10.5152/akd.2014.5637