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Anti–High Mobility Group Box 1 Antibody Therapy May Prevent Cognitive Dysfunction After Traumatic Brain Injury
- Source :
- World Neurosurgery. 122:e864-e871
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Background High mobility group box 1 (HMGB1) protein plays a key role in triggering inflammatory responses in many diseases. Our previous study showed that HMGB1 is found upstream of secondary damage in traumatic brain injury (TBI). We found that anti-HMGB1 monoclonal antibody (mAb) effectively decreased acute brain damage, including the disruption of the blood-brain barrier, brain edema, and neurologic dysfunction. This effect of anti-HMGB1 mAb lasts for at least 1 week. In this study, we explored subacute effects of anti-HMGB1 mAb after TBI. Methods TBI was induced in rats by fluid percussion. Anti-HMGB1 mAb or control mAb was given intravenously after TBI. Histochemical staining, plasma levels of HMGB1, motor activity and memory, and video electroencephalography monitoring were evaluated 2 weeks after fluid percussion injury. Results Anti-HMGB1 mAb remarkably attenuated accumulation of activated microglia in the rat cortex in the ipsilateral hemisphere after TBI. Anti-HMGB1 mAb also prevented neuronal death in the hippocampus in the ipsilateral hemisphere after TBI. Treatment of rats with anti-HMGB1 mAb inhibited HMGB1 translocation and suppressed impairment of motor function. The beneficial effects of anti-HMGB1 mAb on motor and cognitive function persisted for 14 days after injury. Treatment with anti-HMGB1 mAb also had positive effects on electroencephalography activity. Conclusions The beneficial effects of anti-HMGB1 mAb continued during the subacute postinjury phase, suggesting that anti-HMGB1 mAb may prevent cognitive dysfunction after TBI.
- Subjects :
- Male
medicine.drug_class
Traumatic brain injury
Hippocampus
chemical and pharmacologic phenomena
Brain damage
Electroencephalography
Pharmacology
Monoclonal antibody
HMGB1
03 medical and health sciences
0302 clinical medicine
Brain Injuries, Traumatic
medicine
Animals
Cognitive Dysfunction
HMGB1 Protein
Rats, Wistar
Microglia
medicine.diagnostic_test
biology
business.industry
Antibodies, Monoclonal
medicine.disease
Rats
Cortex (botany)
medicine.anatomical_structure
030220 oncology & carcinogenesis
biology.protein
Surgery
Neurology (clinical)
medicine.symptom
business
030217 neurology & neurosurgery
Protein Binding
Subjects
Details
- ISSN :
- 18788750
- Volume :
- 122
- Database :
- OpenAIRE
- Journal :
- World Neurosurgery
- Accession number :
- edsair.doi.dedup.....2381343a50bd1d5eb0113f361c4852a0