Back to Search
Start Over
Quantifying the Link between Anatomical Connectivity, Gray Matter Volume and Regional Cerebral Blood Flow: An Integrative MRI Study
- Source :
- PLoS One, PLoS ONE, PLoS ONE, Vol 6, Iss 4, p e14801 (2011)
- Publication Year :
- 2011
-
Abstract
- BackgroundIn the graph theoretical analysis of anatomical brain connectivity, the white matter connections between regions of the brain are identified and serve as basis for the assessment of regional connectivity profiles, for example, to locate the hubs of the brain. But regions of the brain can be characterised further with respect to their gray matter volume or resting state perfusion. Local anatomical connectivity, gray matter volume and perfusion are traits of each brain region that are likely to be interdependent, however, particular patterns of systematic covariation have not yet been identified.Methodology/principal findingsWe quantified the covariation of these traits by conducting an integrative MRI study on 23 subjects, utilising a combination of Diffusion Tensor Imaging, Arterial Spin Labeling and anatomical imaging. Based on our hypothesis that local connectivity, gray matter volume and perfusion are linked, we correlated these measures and particularly isolated the covariation of connectivity and perfusion by statistically controlling for gray matter volume. We found significant levels of covariation on the group- and regionwise level, particularly in regions of the Default Brain Mode Network.Conclusions/significanceConnectivity and perfusion are systematically linked throughout a number of brain regions, thus we discuss these results as a starting point for further research on the role of homology in the formation of functional connectivity networks and on how structure/function relationships can manifest in the form of such trait interdependency.
- Subjects :
- Adult
Male
Connectomics
Pathology
medicine.medical_specialty
Nerve net
Science
Biology
Gray (unit)
030218 nuclear medicine & medical imaging
White matter
03 medical and health sciences
Young Adult
0302 clinical medicine
medicine
Humans
Neuroscience/Theoretical Neuroscience
Multidisciplinary
Computational Biology/Systems Biology
Resting state fMRI
medicine.diagnostic_test
Computational Biology
Brain
Magnetic resonance imaging
Organ Size
Middle Aged
Neuroscience/Neurodevelopment
Magnetic Resonance Imaging
Perfusion
medicine.anatomical_structure
Cerebral blood flow
Cerebrovascular Circulation
Medicine
Female
Nerve Net
Neuroscience
030217 neurology & neurosurgery
Diffusion MRI
Research Article
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- PLoS One, PLoS ONE, PLoS ONE, Vol 6, Iss 4, p e14801 (2011)
- Accession number :
- edsair.doi.dedup.....2379110d54d460b226b4b96f8ffad89a