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Microfluidic and Paper-Based Devices for Disease Detection and Diagnostic Research
- Source :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences, Vol 19, Iss 9, p 2731 (2018)
- Publication Year :
- 2018
- Publisher :
- MDPI, 2018.
-
Abstract
- Recent developments in microfluidic devices, nanoparticle chemistry, fluorescent microscopy, and biochemical techniques such as genetic identification and antibody capture have provided easier and more sensitive platforms for detecting and diagnosing diseases as well as providing new fundamental insight into disease progression. These advancements have led to the development of new technology and assays capable of easy and early detection of pathogenicity as well as the enhancement of the drug discovery and development pipeline. While some studies have focused on treatment, many of these technologies have found initial success in laboratories as a precursor for clinical applications. This review highlights the current and future progress of microfluidic techniques geared toward the timely and inexpensive diagnosis of disease including technologies aimed at high-throughput single cell analysis for drug development. It also summarizes novel microfluidic approaches to characterize fundamental cellular behavior and heterogeneity.
- Subjects :
- 0301 basic medicine
Disease detection
Computer science
Point-of-Care Systems
Microfluidics
Early detection
single cell analysis
Nanotechnology
Review
high-throughput screening
Catalysis
Inorganic Chemistry
lcsh:Chemistry
03 medical and health sciences
PDMS
Lab-On-A-Chip Devices
Humans
polydimethylsiloxane
Dimethylpolysiloxanes
Physical and Theoretical Chemistry
Molecular Biology
lcsh:QH301-705.5
microfluidic devices
Spectroscopy
Drug discovery
Capture antibody
lateral flow strip assays
Organic Chemistry
Disease progression
µPADs
General Medicine
Paper based
Equipment Design
Microfluidic Analytical Techniques
point of care
3. Good health
Computer Science Applications
030104 developmental biology
Drug development
lcsh:Biology (General)
lcsh:QD1-999
Single-Cell Analysis
LFSAs
Subjects
Details
- Language :
- English
- ISSN :
- 14220067
- Volume :
- 19
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....237192acd28a761e3849e979a4c92a53