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Exercise training prevents the development of cardiac dysfunction in the low-dose streptozotocin diabetic rats fed a high-fat diet
- Source :
- Canadian Journal of Physiology and Pharmacology. 91:80-89
- Publication Year :
- 2013
- Publisher :
- Canadian Science Publishing, 2013.
-
Abstract
- This study tested the hypothesis that exercise training would prevent the development of diabetes-induced cardiac dysfunction and altered expression of sarcoplasmic reticulum Ca2 +-transport proteins in the low-dose streptozotocin-induced diabetic rats fed a high-fat diet (HFD+STZ). Male Sprague–Dawley rats (4 weeks old; 125–150 g) were made diabetic using a high-fat diet (40% fat, w/w) and a low-dose of streptozotocin (35 mg·(kg body mass)–1) by intravenous injection. Diabetic animals were divided among a sedentary group (Sed+HFD+STZ) or an exercise-trained group (Ex+HFD+STZ) that accumulated 3554 ± 338 m·day–1of voluntary wheel running (mean ± SE). Sedentary animals fed a low-fat diet served as the control (Sed+LFD). Oral glucose tolerance was impaired in the sedentary diabetic group (1179 ± 29; area under the curve (a.u.c.)) compared with that in the sedentary control animals (1447 ± 42 a.u.c.). Although left ventricular systolic function was unchanged by diabetes, impaired E/A ratios (i.e., diastolic function) and rates of pressure decay (–dP/dt) indicated the presence of diastolic dysfunction. Diabetes also reduced SERCA2a protein content and maximal SERCA2a activity (Vmax) by 21% and 32%, respectively. In contrast, the change in each parameter was attenuated by exercise training. Based on these data, it appears that exercise training prevented the development of diabetic cardiomyopathy and the dysregulation of sarcoplasmic reticulum protein content in an inducible animal model of type 2 diabetes.
- Subjects :
- Male
medicine.medical_specialty
SERCA
Diabetic Cardiomyopathies
Physiology
Diastole
Diet, High-Fat
Streptozocin
Ventricular Function, Left
Diabetes Mellitus, Experimental
Rats, Sprague-Dawley
Ventricular Dysfunction, Left
Physical Conditioning, Animal
Physiology (medical)
Diabetes mellitus
Internal medicine
medicine
Animals
computer.programming_language
Pharmacology
Dose-Response Relationship, Drug
sed
business.industry
Area under the curve
General Medicine
Streptozotocin
medicine.disease
Dietary Fats
Rats
Phospholamban
Dose–response relationship
Endocrinology
Echocardiography
business
computer
medicine.drug
Subjects
Details
- ISSN :
- 12057541 and 00084212
- Volume :
- 91
- Database :
- OpenAIRE
- Journal :
- Canadian Journal of Physiology and Pharmacology
- Accession number :
- edsair.doi.dedup.....236ed2300f51a3ce203cee8e9292c5fc