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Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis
- Source :
- Lin, C P, Adrianto, I, Lessard, C J, Kelly, J, Kaufman, K M, Guthridge, J M, Freedman, B I, Anaya, J-M, Alarcón-Riquelme, M E, Pons-Estel, B A, Martin, J, Glenn, S, Adler, A, Bae, S-C, Park, S-Y, Bang, S-Y, Song, Y-W, Boackle, S A, Brown, E E, Edberg, J C, Alarcón, G S, Petri, M A, Criswell, L A, Ramsey-Goldman, R, Reveille, J D, Vila, L M, Gilkeson, G S, Kamen, D L, Ziegler, J, Jacob, C O, Rasmussen, A, James, J A, Kimberly, R P, Merrill, J T, Niewold, T B, Scofield, R H, Stevens, A M, Tsao, B P, Vyse, T J, Langefeld, C D, Moser, K, Harley, J B, Gaffney, P M, Montgomery, C G, BIOLUPUS and GENLES Networks, Junker, P, Voss, A & Laustrup, H 2012, ' Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis ', Genes and Immunity, vol. 13, no. 3, pp. 232-8 . https://doi.org/10.1038/gene.2011.82, Repositorio EdocUR-U. Rosario, Universidad del Rosario, instacron:Universidad del Rosario, Digital.CSIC. Repositorio Institucional del CSIC, instname
- Publication Year :
- 2011
-
Abstract
- Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by autoantibody production and organ damage. Lupus nephritis (LN) is one of the most severe manifestations of SLE. Multiple studies reported associations between renal diseases and variants in the non-muscle myosin heavy chain 9 (MYH9) and the neighboring apolipoprotein L 1 (APOL1) genes. We evaluated 167 variants spanning MYH9 for association with LN in a multiethnic sample. The two previously identified risk variants in APOL1 were also tested for association with LN in European-Americans (EAs) (N=579) and African-Americans (AAs) (N=407). Multiple peaks of association exceeding a Bonferroni corrected P-value of P
- Subjects :
- single nucleotide
Linkage disequilibrium
Unclassified drug
Lupus nephritis
Hispanic
Genome-wide association study
Linkage Disequilibrium
Myh9
Polymorphism (computer science)
Genetics (clinical)
Priority journal
African Americans
education.field_of_study
Apolipoprotein l 1
Molecular Motor Proteins
Apolipoprotein L1
Lupus Nephritis
Apolipoprotein
Apolipoprotein L
American indian
Lipoproteins, HDL
Human
Lipoproteins
Immunology
Population
European Continental Ancestry Group
Major clinical study
Biology
Polymorphism, Single Nucleotide
White People
Article
European american
Systemic lupus erythematosus
Genetics
medicine
Humans
Genetic Predisposition to Disease
African american
Polymorphism
education
Autoimmune disease
hdl
Asian
Myosin Heavy Chains
Odds ratio
Apol1
medicine.disease
Myosin heavy chain 9
Black or African American
Apolipoproteins
Lupus erythematosus nephritis
Multiethnic association study
Myosin heavy chain
Controlled study
Subjects
Details
- ISSN :
- 14765470
- Volume :
- 13
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Genes and immunity
- Accession number :
- edsair.doi.dedup.....236cbb6b865a3be2e2d6d1358303efdf
- Full Text :
- https://doi.org/10.1038/gene.2011.82