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Conditioned climbing fiber responses in cerebellar cortex and nuclei
- Source :
- Neuroscience Letters, 688, 26-36. Elsevier Ireland Ltd, Neuroscience Letters
- Publication Year :
- 2018
-
Abstract
- The eyeblink conditioning paradigm captures an elementary form of associative learning in a neural circuitry that is understood to an extraordinary degree. Cerebellar cortical Purkinje cell simple spike suppression is widely regarded as the main process underlying conditioned responses (CRs), leading to disinhibition of neurons in the cerebellar nuclei that innervate eyelid muscles downstream. However, recent work highlights the addition of a conditioned Purkinje cell complex spike response, which at the level of the interposed nucleus seems to translate to a transient spike suppression that can be followed by a rapid spike facilitation. Here, we review the characteristics of these responses at the cerebellar cortical and nuclear level, and discuss possible origins and functions.
- Subjects :
- 0301 basic medicine
Purkinje cell
Conditioning, Classical
Action Potentials
Review
Biology
03 medical and health sciences
Cerebellar Cortex
Purkinje Cells
0302 clinical medicine
Interposed nucleus
Neural Pathways
medicine
Biological neural network
Journal Article
Animals
Blinking
General Neuroscience
Neural Inhibition
Climbing fiber
Associative learning
030104 developmental biology
medicine.anatomical_structure
Eyeblink conditioning
Cerebellar Nuclei
Disinhibition
Cerebellar cortex
medicine.symptom
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 18727972 and 03043940
- Volume :
- 688
- Database :
- OpenAIRE
- Journal :
- Neuroscience letters
- Accession number :
- edsair.doi.dedup.....235079d121f0cc20174046ac9ac90605