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Remote Ischemic Perconditioning Ameliorates Myocardial Ischemia and Reperfusion-Induced Coronary Endothelial Dysfunction and Aortic Stiffness in Rats
- Source :
- Journal of Cardiovascular Pharmacology and Therapeutics
- Publication Year :
- 2021
- Publisher :
- SAGE Publications, 2021.
-
Abstract
- Background: Vascular stiffness and endothelial dysfunction are accelerated by acute myocardial infarction (AMI) and subsequently increase the risk for recurrent coronary events. Aim: To explore whether remote ischemic perconditioning (RIPerc) protects against coronary and aorta endothelial dysfunction as well as aortic stiffness following AMI. Methods: Male OFA-1 rats were subjected to 30 min of occlusion of the left anterior descending artery (LAD) followed by reperfusion either 3 or 28 days with or without RIPerc. Three groups: (1) sham operated (Sham, without LAD occlusion); (2) myocardial ischemia and reperfusion (MIR) and (3) MIR + RIPerc group with 3 cycles of 5 minutes of IR on hindlimb performed during myocardial ischemia were used. Assessment of vascular reactivity in isolated septal coronary arteries (non-occluded) and aortic rings as well as aortic stiffness was assessed by wire myography either 3 or 28 days after AMI, respectively. Markers of pro-inflammatory cytokines, adhesion molecules were assessed by RT-qPCR and ELISA. Results: MIR promotes impaired endothelial-dependent relaxation in septal coronary artery segments, increased aortic stiffness and adverse left ventricular remodeling. These changes were markedly attenuated in rats treated with RIPerc and associated with a significant decline in P-selectin, IL-6 and TNF-α expression either in infarcted or non-infarcted myocardial tissue samples. Conclusions: Our study for the first time demonstrated that RIPerc alleviates MIR-induced coronary artery endothelial dysfunction in non-occluded artery segments and attenuates aortic stiffness in rats. The vascular protective effects of RIPerc are associated with ameliorated inflammation and might therefore be caused by reduced inflammatory signaling.
- Subjects :
- Male
medicine.medical_specialty
Myocardial ischemia
endothelium
Endothelium
Heart disease
ischemia-reperfusion injury
Myocardial Infarction
Myocardial Ischemia
acute myocardial infarction
Myocardial Reperfusion
Myocardial Reperfusion Injury
heart disease
030204 cardiovascular system & hematology
03 medical and health sciences
Vascular Stiffness
0302 clinical medicine
Vascular stiffness
Internal medicine
medicine
Animals
Pharmacology (medical)
cardiovascular diseases
030212 general & internal medicine
Myocardial infarction
Endothelial dysfunction
Inflammation
Pharmacology
business.industry
medicine.disease
Coronary Vessels
Rats
Experimental Studies
medicine.anatomical_structure
Ischemic Preconditioning, Myocardial
Cardiology
Cytokines
Aortic stiffness
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 19404034 and 10742484
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Journal of Cardiovascular Pharmacology and Therapeutics
- Accession number :
- edsair.doi.dedup.....23468c1dbbcfde381a00a5ccedc11c6b