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Pathogenesis and Prognosis of Hepatocellular Carcinoma at the Cellular and Molecular Levels
- Source :
- Clinics in Liver Disease. 19:261-276
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- Different approaches predict the outcome for patients with hepatocellular carcinoma (HCC). The expression of biliary-hepatic progenitor cell markers generally correlates with poor prognosis. This article focuses on the pathogenesis of HCC, how differentiation or dedifferentiation leads to a phenotype switch, and heterogeneity in the same tumor. A tumor cell decides its fate based on a complex interplay of signaling pathways. Interaction with the microenvironment decides whether it will invade, proliferate, or enter survival mode. Several signaling pathways contribute to stemness features, reflecting a small chemoresistant subpopulation of the tumor that expresses biliary-hepatic progenitor cell markers.
- Subjects :
- Oncology
medicine.medical_specialty
Poor prognosis
Carcinoma, Hepatocellular
Cell of origin
Cell Plasticity
Tumor cells
Pathogenesis
Internal medicine
Tumor Microenvironment
Humans
Medicine
Progenitor cell
Hepatology
business.industry
Liver Neoplasms
Cell Differentiation
Cell Dedifferentiation
Prognosis
medicine.disease
Phenotype
Hepatocellular carcinoma
Cancer research
Signal transduction
Transcriptome
business
Subjects
Details
- ISSN :
- 10893261
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Clinics in Liver Disease
- Accession number :
- edsair.doi.dedup.....234091448ca065fe32b4cb7b985fd0e3