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Identification of a pharmacogenetic effect by linkage disequilibrium mapping
- Source :
- The pharmacogenomics journal. 4(6)
- Publication Year :
- 2004
-
Abstract
- A practical limitation to the identification of genetic profiles predictive of drug-induced adverse events is the number of patients with the adverse event that can be tolerated before the drug is withdrawn. Whole genome screening for regions of linkage disequilibrium (LD) associated with a particular phenotype may provide the mechanism to rapidly discover specific and sensitive profiles. We have used data from a large phase III clinical trial of tranilast and typed 76 SNPs over a 2.7 megabase region flanking the uridine diphosphate glucuronosyltranserferase 1A1 gene. Three SNPs within one LD block showed strong association with tranilast-induced hyperbilirubinemia (P
- Subjects :
- Pharmacology
Genetics
Linkage disequilibrium
Linkage Disequilibrium Mapping
Single-nucleotide polymorphism
Biology
Genome
Polymorphism, Single Nucleotide
Linkage Disequilibrium
Clinical Trials, Phase III as Topic
Polymorphism (computer science)
Pharmacogenetics
Molecular Medicine
Humans
ortho-Aminobenzoates
Glucuronosyltransferase
Adverse effect
Gene
Subjects
Details
- ISSN :
- 1470269X
- Volume :
- 4
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- The pharmacogenomics journal
- Accession number :
- edsair.doi.dedup.....233dfdbe9b69f4ed2b5926098139d740