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Chemical Stimulation of Renal Tissue Induces Sympathetic Activation and a Pressor Response via the Paraventricular Nucleus in Rats
- Source :
- Neurosci Bull
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Sympathetic activation and the kidney play critical roles in hypertension and chronic heart failure. The role of the kidney in sympathetic activation is still not well known. In this study, we revealed an excitatory renal reflex (ERR) in rats induced by chemical stimulation of the kidney that regulated sympathetic activity and blood pressure. The ERR was induced by renal infusion of capsaicin, and evaluated by the changes in renal sympathetic outflow, blood pressure, and heart rate. Renal infusion of capsaicin dose-dependently increased the contralateral renal sympathetic nerve activity, mean arterial pressure, and heart rate. Capsaicin in the cortico-medullary border had greater effects than in the cortex or medulla. Intravenous infusion of capsaicin had no significant effects. The effects of renal infusion of capsaicin were abolished by ipsilateral renal denervation, but were not affected by bilateral sinoaortic denervation. Renal infusion of capsaicin increased the ipsilateral renal afferent activity. The ERR was also induced by renal infusion of bradykinin, adenosine, and angiotensin II, but not by ATP. Renal infusion of capsaicin increased c-Fos expression in the paraventricular nucleus (PVN) of hypothalamus. Lesion of neurons in the PVN with kainic acid abolished the capsaicin-induced ERR. These findings indicate that chemical stimulation of kidney causes an excitatory reflex, leading to sympathetic activation, pressor response, and accelerated heart rate. The PVN is an important central nucleus in the pathway of the ERR. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12264-019-00417-1) contains supplementary material, which is available to authorized users.
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
Mean arterial pressure
Sympathetic Nervous System
Physiology
Blood Pressure
Bradykinin
Kidney
urologic and male genital diseases
Rats, Sprague-Dawley
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Heart Rate
Internal medicine
Reflex
Heart rate
Animals
Medicine
Arterial Pressure
Denervation
business.industry
Angiotensin II
General Neuroscience
General Medicine
Stimulation, Chemical
Rats
030104 developmental biology
medicine.anatomical_structure
Endocrinology
chemistry
Hypothalamus
Capsaicin
Hypertension
Original Article
business
Proto-Oncogene Proteins c-fos
030217 neurology & neurosurgery
Paraventricular Hypothalamic Nucleus
Subjects
Details
- ISSN :
- 19958218 and 16737067
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Neuroscience Bulletin
- Accession number :
- edsair.doi.dedup.....233de95b10b524bb07d36543a4dbc4e1