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Clear Cell Proliferations of the Skin: A Histopathologic Review
- Source :
- AMERICAN JOURNAL OF DERMATOPATHOLOGY, r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe, instname
- Publication Year :
- 2021
- Publisher :
- LIPPINCOTT WILLIAMS & WILKINS, 2021.
-
Abstract
- Cutaneous clear cell proliferations encompass a heterogenous group of several primary cutaneous neoplasms and metastatic tumors with different histogenesis. Many of these clear cell proliferations may seem strikingly similar under the microscope resulting in challenging diagnosis. In many of these clear cell lesions, the reason for the clear or pale appearance of proliferating cells is unknown, whereas in other ones, this clear cell appearance is due to intracytoplasmic accumulation of glycogen, mucin, or lipid. Artifacts of tissue processing and degenerative phenomenon may also be responsible for the clear cell appearance of proliferating cells. Awareness of the histopathologic findings as well as histochemical and immunohistochemical techniques are crucial to the accurate diagnosis. This review details the histopathologic features of clear cell cutaneous proliferations, classifying them according their type of differentiation and paying special attention to the histopathologic differential diagnosis among them.
- Subjects :
- Pathology
medicine.medical_specialty
Skin Neoplasms
Perivascular Epithelioid Cell Neoplasms
Hemangiosarcoma
Dermatology
Histogenesis
Pathology and Forensic Medicine
medicine
Xanthomatosis
Humans
Sebaceous Gland Neoplasms
Keratosis, Seborrheic
Melanoma
Neurofibroma
Histiocytoma, Benign Fibrous
business.industry
Mucin
General Medicine
Liposarcoma
cutaneous neoplasms
clear cells
Immunohistochemistry
Sweat Gland Neoplasms
Carcinoma, Basal Cell
Granular Cell Tumor
immunohistochemistry
Carcinoma, Squamous Cell
pale cells
Acanthoma
Differential diagnosis
Epidermis
business
Hair Follicle
Clear cell
Subjects
Details
- ISSN :
- 01931091
- Database :
- OpenAIRE
- Journal :
- AMERICAN JOURNAL OF DERMATOPATHOLOGY, r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe, instname
- Accession number :
- edsair.doi.dedup.....2329a258d6823a1f861c4800a2f76f4d