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Identification and in vitro antifungal susceptibility testing of 200 clinical isolates of Candida spp. responsible for fingernail infections
- Source :
- Mycopathologia. 164:27-33
- Publication Year :
- 2007
- Publisher :
- Springer Science and Business Media LLC, 2007.
-
Abstract
- A total of 200 samples of Candida spp. that are responsible for fingernail infections were isolated in Belo Horizonte, MG, Brazil from April 2004 to May 2005. The samples were identified by routine microbiological techniques and had the following distribution: Candida parapsilosis (40.5%), C. albicans (31.5%), C. tropicalis (26%), and C. guilliermondii (2%). We performed in vitro susceptibility tests with ciclopiroxolamine, terbinafine, ketoconazole, itraconazole, and fluconazole using the CLSI (Clinical and Laboratory Standards Institute) and EUCAST (European Committee on Antibiotic Susceptibility Testing) methodologies. The percentages of agreement between the two methodologies varied from 48 to 100% (the percentage increased to more than 60% for the majority of the samples). Percentages of agreement between the methodologies lower than 60% were seen with ketoconazole (57%) and itraconazole (48%) for samples of C. albicans and with fluconazole (54%) for samples of C. tropicalis. In general, we observed higher agreement between the values of the MICs obtained with both methodologies for ciclopiroxolamine and terbinafine for all tested species. With azoles, lower percentages of agreement between the methodologies were observed for samples C. albicans and C. tropicalis.
- Subjects :
- medicine.medical_specialty
Antifungal Agents
Miconazole
Pyridones
Itraconazole
medicine.drug_class
Veterinary (miscellaneous)
Antibiotics
Hand Dermatoses
Microbial Sensitivity Tests
Naphthalenes
Biology
Candida parapsilosis
Applied Microbiology and Biotechnology
Microbiology
Medical microbiology
Onychomycosis
medicine
Humans
Fluconazole
Terbinafine
Candida
Candidiasis
Ciclopirox
biology.organism_classification
Corpus albicans
Ketoconazole
Agronomy and Crop Science
Brazil
medicine.drug
Subjects
Details
- ISSN :
- 15730832 and 0301486X
- Volume :
- 164
- Database :
- OpenAIRE
- Journal :
- Mycopathologia
- Accession number :
- edsair.doi.dedup.....2324b2871fe6fa86be1368059cbb8bb9