Identification of Acyl Protein Thioesterases 1 and 2 as the Cellular Targets of the Ras-Signaling Modulators Palmostatin B and M

Authors :: Marco Bürger
Stephan A. Sieber
Christian Hedberg
Ingrid R. Vetter
Thomas Böttcher
Andreas Brockmeyer
Kristina Görmer
Frank J. Dekker
Herbert Waldmann
Gemma Triola
Marion Rusch
Tobias J. Zimmermann
Petra Janning
Groningen Research Institute of Pharmacy
Biopharmaceuticals, Discovery, Design and Delivery (BDDD)
Medicinal Chemistry and Bioanalysis (MCB)
Source :: Angewandte Chemie-International Edition, 50(42), 9838-9842. WILEY-V C H VERLAG GMBH, Angewandte Chemie
Publication Year :: 2011
Publisher :: Wiley, 2011.
Abstract: Finding the target: activity-based proteomic profiling probes based on the depalmitoylation inhibitors palmostatin B and M have been synthesized and were found to target acyl protein thioesterase 1 (APT1) and 2 (APT2) in cells.

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