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Association of body mass index with kidney function and mortality in high cardiovascular risk population: A nationwide prospective cohort study
- Source :
- Nephrology (Carlton, Vic.)REFERENCES. 27(1)
- Publication Year :
- 2021
-
Abstract
- BACKGROUND There is increasing awareness of the impact of obesity and underweight on cardiovascular (CV) disease, chronic kidney disease (CKD) and mortality. Abnormal body mass index (BMI) might be associated with worse clinical outcomes, including CKD progression, but limited evidence exists among Asian patients with high CV risk. OBJECTIVE To investigate the association of BMI with progressive loss of kidney function and all-cause mortality in Thai patients with high CV risk. METHODS In a national cohort of 5887 high CV risk subjects, we assessed the association of high BMI with the composite renal outcome (estimated glomerular filtration rate [eGFR] decline over 40%, eGFR less than 15 mL/min/1.73 m2 , doubling of serum creatinine, initiation of dialysis and death related to renal causes) and with all-cause mortality in Cox proportional hazards models. RESULTS A total of 5887 participants (3217 male and 2670 female) with high CV risk were enrolled. Participants were classified into five groups by their baseline BMI
- Subjects :
- Male
medicine.medical_specialty
medicine.medical_treatment
Population
Renal function
Kidney Function Tests
Risk Assessment
End stage renal disease
Body Mass Index
Risk Factors
Internal medicine
medicine
Humans
Obesity
Prospective Studies
education
Prospective cohort study
Dialysis
Aged
Proportional Hazards Models
education.field_of_study
Proportional hazards model
business.industry
General Medicine
medicine.disease
Thailand
Nephrology
Cardiovascular Diseases
Heart Disease Risk Factors
Creatinine
Kidney Failure, Chronic
Female
business
Body mass index
Kidney disease
Glomerular Filtration Rate
Subjects
Details
- ISSN :
- 14401797
- Volume :
- 27
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Nephrology (Carlton, Vic.)REFERENCES
- Accession number :
- edsair.doi.dedup.....230befbe4671ed06821ebb5d149ee0c4