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Bombesin receptor subtype‐3‐expressing neurons regulate energy homeostasis through a novel neuronal pathway in the hypothalamus
- Source :
- Brain and Behavior
- Publication Year :
- 2017
- Publisher :
- John Wiley and Sons Inc., 2017.
-
Abstract
- Objectives Bombesin receptor subtype‐3 (BRS‐3) has been suggested to play a potential role in energy homeostasis. However, the physiological mechanism of BRS‐3 on energy homeostasis remains unknown. Thus, we investigated the BRS‐3‐mediated neuronal pathway involved in food intake and energy expenditure. Materials and Methods Expression of BRS‐3 in the rat brain was histologically examined. The BRS‐3 neurons activated by refeeding‐induced satiety or a BRS‐3 agonist were identified by c‐Fos immunostaining. We also analyzed expression changes in feeding‐relating peptides in the brain of fasted rats administered with the BRS‐3 agonist. Results In the paraventricular hypothalamic nucleus (PVH), dorsomedial hypothalamic nucleus (DMH), and medial preoptic area (MPA), strong c‐Fos induction was observed in the BRS‐3 neurons especially in PVH after refeeding. However, the BRS‐3 neurons in the PVH did not express feeding‐regulating peptides, while the BRS‐3 agonist administration induced c‐Fos expression in the DMH and MPA, which were not refeeding‐sensitive, as well as in the PVH. The BRS‐3 agonist administration changed the Pomc and Cart mRNA level in several brain regions of fasted rats. Conclusion These results suggest that BRS‐3 neurons in the PVH are a novel functional subdivision in the PVH that regulates feeding behavior. As the MPA and DMH are reportedly involved in thermoregulation and energy metabolism, the BRS‐3 neurons in the MPA/DMH might mediate the energy expenditure control. POMC and CART may contribute to BRS‐3 neuron‐mediated energy homeostasis regulation. In summary, BRS‐3‐expressing neurons could regulate energy homeostasis through a novel neuronal pathway.
- Subjects :
- 0301 basic medicine
Agonist
Male
medicine.medical_specialty
obesity
medicine.drug_class
Hypothalamus
Nerve Tissue Proteins
CHO Cells
Biology
Energy homeostasis
Rats, Sprague-Dawley
03 medical and health sciences
Behavioral Neuroscience
bombesin receptor subtype‐3
Eating
Cricetulus
Internal medicine
medicine
Animals
Homeostasis
Receptors, Somatostatin
Dorsomedial hypothalamic nucleus
energy homeostasis
Original Research
Mice, Knockout
Neurons
fungi
Feeding Behavior
Thermoregulation
Bombesin receptor
Rats
Receptors, Bombesin
030104 developmental biology
Endocrinology
nervous system
neuronal pathway
Bombesin Receptor Subtype-3
Energy Metabolism
Immunostaining
Subjects
Details
- Language :
- English
- ISSN :
- 21623279
- Volume :
- 8
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Brain and Behavior
- Accession number :
- edsair.doi.dedup.....2300aeb97de7571557d5da15532e6a1f