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High-dose preoperative cholecalciferol to prevent post-thyroidectomy hypocalcaemia: A randomized, double-blinded placebo-controlled trial
High-dose preoperative cholecalciferol to prevent post-thyroidectomy hypocalcaemia: A randomized, double-blinded placebo-controlled trial
- Source :
- Clinical endocrinology. 90(2)
- Publication Year :
- 2018
-
Abstract
- OBJECTIVE Post-thyroidectomy hypocalcaemia is a significant cause of morbidity and prolonged hospitalization, usually due to transient parathyroid gland damage, treated with calcium and vitamin D supplementation. We present a randomized, double-blinded placebo-controlled trial of preoperative loading with high-dose cholecalciferol (300 000 IU) to reduce post-thyroidectomy hypocalcaemia. PATIENTS AND MEASUREMENTS Patients (n = 160) presenting for thyroidectomy at tertiary hospitals were randomized 1:1 to cholecalciferol (300 000 IU) or placebo 7 days prior to thyroidectomy. Ten patients withdrew prior to surgery. The primary outcome was post-operative hypocalcaemia (corrected calcium
- Subjects :
- musculoskeletal diseases
Adult
Male
medicine.medical_specialty
Calcium-Regulating Hormones and Agents
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Premedication
Placebo-controlled study
Parathyroid hormone
030209 endocrinology & metabolism
Placebo
Gastroenterology
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
Internal medicine
Preoperative Care
medicine
Vitamin D and neurology
Humans
Hypocalcaemia
Cholecalciferol
Hypocalcemia
business.industry
Thyroidectomy
Middle Aged
medicine.disease
medicine.anatomical_structure
Treatment Outcome
chemistry
030220 oncology & carcinogenesis
Parathyroid gland
Female
business
Subjects
Details
- ISSN :
- 13652265
- Volume :
- 90
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Clinical endocrinology
- Accession number :
- edsair.doi.dedup.....22fc38eb6b925cdb719b3aabc78b8652