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High-dose preoperative cholecalciferol to prevent post-thyroidectomy hypocalcaemia: A randomized, double-blinded placebo-controlled trial

High-dose preoperative cholecalciferol to prevent post-thyroidectomy hypocalcaemia: A randomized, double-blinded placebo-controlled trial

Authors :
Katie Wynne
Christine J. O'Neill
Rosemary Carroll
Christopher W. Rowe
Jacqueline Hawthorne
Cino Bendinelli
Sam Arthurs
Source :
Clinical endocrinology. 90(2)
Publication Year :
2018

Abstract

OBJECTIVE Post-thyroidectomy hypocalcaemia is a significant cause of morbidity and prolonged hospitalization, usually due to transient parathyroid gland damage, treated with calcium and vitamin D supplementation. We present a randomized, double-blinded placebo-controlled trial of preoperative loading with high-dose cholecalciferol (300 000 IU) to reduce post-thyroidectomy hypocalcaemia. PATIENTS AND MEASUREMENTS Patients (n = 160) presenting for thyroidectomy at tertiary hospitals were randomized 1:1 to cholecalciferol (300 000 IU) or placebo 7 days prior to thyroidectomy. Ten patients withdrew prior to surgery. The primary outcome was post-operative hypocalcaemia (corrected calcium

Details

ISSN :
13652265
Volume :
90
Issue :
2
Database :
OpenAIRE
Journal :
Clinical endocrinology
Accession number :
edsair.doi.dedup.....22fc38eb6b925cdb719b3aabc78b8652