Back to Search
Start Over
Formyl Peptide Receptor (FPR)1 Modulation by Resveratrol in an LPS-Induced Neuroinflammatory Animal Model
- Source :
- Nutrients, Volume 13, Issue 5, Nutrients, Vol 13, Iss 1418, p 1418 (2021)
- Publication Year :
- 2021
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2021.
-
Abstract
- Among therapeutic approaches that have been investigated, targeting of receptors implicated in managing neuroinflammation has been described. One such family of receptors comprises the formyl peptide receptors (FPRs) whose ligands could play a role in host defense. The murine FPR gene family includes at least six members while in humans there are only three. The two most important members are the Fpr1 and Fpr2. Fpr1encodes murine FPR1, which is considered the murine orthologue of human FPR. Resveratrol, a non-flavonoid polyphenol rich in red wine and grapes, apart from its beneficial health effects and anti-inflammatory properties, has been reported to reduce neuroinflammation in different neurodegenerative disease models. Resveratrol anti-inflammatory responses involve the activation of the protein deacetylase sirtuin 1 (SIRT1) gene. In this work we have investigated in an LPS-based murine model of neuroinflammation the role of FPR1, examining not only if this receptor undergoes a reduction of its expression during neuroinflammation, but also whether treatment with resveratrol was able to modulate its expression leading to an amelioration of neuroinflammatory picture in a murine model of neuroinflammation. Results of this work showed that FPR1 together with SIRT1 resulted upregulated by resveratrol treatment and that this increase is associated with an amelioration of the neuroinflammatory picture, as demonstrated by the induction of IL-10 and IL1-RA expression and the downregulation of proinflammatory mediators, such as TNF-α and IL-1β. The expression and the modulation of FPR1 by resveratrol may be evaluated in order to propose a novel anti-inflammatory and pro-resolving therapeutic approach for the reduction of the detrimental effects associated with neuro-inflammation based neurodegenerative diseases and also as a promising strategy to promote human health by a diet rich in antioxidative bioactive compounds.
- Subjects :
- Lipopolysaccharides
Male
0301 basic medicine
Anti-Inflammatory Agents
microglia
Pharmacology
Resveratrol
resveratrol
Models, Biological
Article
Proinflammatory cytokine
neuroinflammation
Mice
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Sirtuin 1
Downregulation and upregulation
Glial Fibrillary Acidic Protein
Animals
TX341-641
RNA, Messenger
Receptor
Neuroinflammation
Inflammation
Nutrition and Dietetics
Formyl peptide receptor
biology
Nutrition. Foods and food supply
Tumor Necrosis Factor-alpha
Chemistry
Calcium-Binding Proteins
Microfilament Proteins
food and beverages
Receptors, Formyl Peptide
FPR, neuroinflammation, neurodegeneration
Disease Models, Animal
Interleukin 1 Receptor Antagonist Protein
030104 developmental biology
nutrition
Astrocytes
biology.protein
Protein deacetylase
Inflammation Mediators
FPR
030217 neurology & neurosurgery
Signal Transduction
Food Science
Subjects
Details
- Language :
- English
- ISSN :
- 20726643
- Database :
- OpenAIRE
- Journal :
- Nutrients
- Accession number :
- edsair.doi.dedup.....22f3a6879c79ca16f8252bb541f76414
- Full Text :
- https://doi.org/10.3390/nu13051418