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Sphingosine-1-phosphate signaling and the gut-liver axis in liver diseases
- Source :
- Liver Research, Vol 3, Iss 1, Pp 19-24 (2019), Liver research
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- The liver is the central organ involved in lipid metabolism and the gastrointestinal (GI) tract is responsible for nutrient absorption and partitioning. Obesity, dyslipidemia and metabolic disorders are of increasing public health concern worldwide, and novel therapeutics that target both the liver and the GI tract (gut-liver axis) are much needed. In addition to aiding fat digestion, bile acids act as important signaling molecules that regulate lipid, glucose and energy metabolism via activating nuclear receptor, G protein-coupled receptors (GPCRs), Takeda G protein receptor 5 (TGR5) and sphingosine-1-phosphate receptor 2 (S1PR2). Sphingosine-1-phosphate (S1P) is synthesized by two sphingosine kinase isoforms and is a potent signaling molecule that plays a critical role in various diseases such as fatty liver, inflammatory bowel disease (IBD) and colorectal cancer. In this review, we will focus on recent findings related to the role of S1P-mediated signaling pathways in the gut-liver axis. Keywords: Sphingosine-1-phosphate (S1P), Sphingosine kinase 2 (SphK2), Sphingosine-1-phosphate receptor 2 (S1PR2), Gut-liver axis, Liver diseases
- Subjects :
- 0301 basic medicine
Cell signaling
Gut-liver axis
Sphingosine kinase
Pharmacology
Article
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
medicine
Sphingosine-1-phosphate
lcsh:RC799-869
Sphingosine-1-phosphate (S1P)
Sphingosine-1-phosphate receptor 2
Liver diseases
S1PR2
Hepatology
Chemistry
Fatty liver
Gastroenterology
Lipid metabolism
medicine.disease
G protein-coupled bile acid receptor
3. Good health
030104 developmental biology
(S1PR2)
Sphingosine kinase 2 (SphK2)
lcsh:Diseases of the digestive system. Gastroenterology
030211 gastroenterology & hepatology
Signal transduction
Subjects
Details
- ISSN :
- 25425684
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- Liver Research
- Accession number :
- edsair.doi.dedup.....22d9437afc26b1d4594bd8db9f79e868