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A drug and ATP binding site in type 1 ryanodine receptor

Authors :
Zephan Melville
Haikel Dridi
Qi Yuan
Steven Reiken
Anetta Wronska
Yang Liu
Oliver B. Clarke
Andrew R. Marks
Source :
Acta Crystallographica Section A Foundations and Advances. 78:a315-a315
Publication Year :
2022
Publisher :
International Union of Crystallography (IUCr), 2022.

Abstract

The ryanodine receptor (RyR)/calcium release channel on the sarcoplasmic reticulum (SR) is required for excitation-contraction coupling in skeletal and cardiac muscle. Inherited mutations and stress-induced post-translational modifications result in an SR Ca

Subjects

Subjects :
Binding Sites
Ryanodine Receptor Calcium Release Channel
Condensed Matter Physics
Biochemistry
Inorganic Chemistry
Sarcoplasmic Reticulum
Adenosine Triphosphate
Structural Biology
Animals
Calcium
General Materials Science
Physical and Theoretical Chemistry
Muscle, Skeletal
Molecular Biology

Details

ISSN :
20532733
Volume :
78
Database :
OpenAIRE
Journal :
Acta Crystallographica Section A Foundations and Advances
Accession number :
edsair.doi.dedup.....22c7103b81edad9655de48cc26e4f032
Full Text :
https://doi.org/10.1107/s205327332209684x
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