Back to Search
Start Over
Gerontolizing Nephrology: Spectrum of Histopathological Findings of Kidney Biopsy in the Elderly
- Source :
- Indian Journal of Nephrology, Indian Journal of Nephrology, Vol 30, Iss 4, Pp 264-269 (2020)
- Publication Year :
- 2020
- Publisher :
- Wolters Kluwer - Medknow, 2020.
-
Abstract
- Introduction: The spectrum of renal disorder in the elderly differs from the younger population. There is a paucity of literature regarding kidney biopsy in elderly. This study aims to highlight the clinical profile and histopathological spectrum of the elderly patient undergoing a renal biopsy. Materials and Methods: This retrospective study included all patients (age ≥60 years) undergoing native renal biopsies from January 2012 to December 2017. The clinical profile, laboratory parameters, and renal biopsy findings of these patients were recorded from the case files. Results: Out of 1656 renal biopsies performed during the study period, 230 (13.9%%) performed on the elderly were included. Mean age was 64.02 ± 7.87 years (Range: 60-87 years), and males were predominant (70.4%). The commonest indication for biopsy was nephrotic syndrome (NS) (49.6%) followed by Rapidly progressive renal failure (RPRF) (20.9%) and Acute Kidney Injury (AKI) (15.7%). The most frequent histological diagnosis was membranous nephropathy (15.2%) followed by amyloidosis (13.9%) and Focal Segmental Glomerulosclerosis (FSGS) (13.0%). The commonest cause of NS was MGN (29.8%) followed by FSGS (24.6%) and amyloidosis (22.8%). The commonest cause of nephritic syndrome was Diffuse Proliferative Glomerulonephritis (29.4%) and Membranoproliferative Glomerulonephritis (29.4%). Hypertensive nephrosclerosis (40.0%) and diabetic nephropathy (26.7%)) were the commonest histological diagnosis in the patients who underwent renal biopsy for clinical Chronic kidney disease. Crescentic GN (35.4%) and Myeloma cast nephropathy 14.6%) were the commonest cause of RPRF while Acute Tubular Necrosis (41.7%) was the commonest cause of AKI. None of the patients had major complications. Conclusion: Renal biopsy is safe in the elderly and provides a wealth of information with regards to the diagnosis and prognosis of renal disorder.
- Subjects :
- Nephrology
medicine.medical_specialty
medicine.diagnostic_test
business.industry
nephrotic syndrome
Acute kidney injury
India
lcsh:Diseases of the genitourinary system. Urology
lcsh:RC870-923
medicine.disease
urologic and male genital diseases
Gastroenterology
Focal segmental glomerulosclerosis
Elderly
Membranous nephropathy
renal biopsy
Internal medicine
Biopsy
medicine
Original Article
Renal biopsy
Myeloma cast nephropathy
business
Kidney disease
Subjects
Details
- Language :
- English
- ISSN :
- 19983662 and 09714065
- Volume :
- 30
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Indian Journal of Nephrology
- Accession number :
- edsair.doi.dedup.....22bf2c7f6736f844323e822c45cc252c