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Emerging targets for the diagnosis of Parkinson's disease: examination of systemic biomarkers
- Source :
- Biomark Med
- Publication Year :
- 2021
-
Abstract
- Parkinson’s disease (PD) is a highly prevalent and irreversible neurodegenerative disorder that is typically diagnosed in an advanced stage. Currently, there are no approved biomarkers that reliably identify PD patients before they have undergone extensive neuronal damage, eliminating the opportunity for future disease-modifying therapies to intervene in disease progression. This unmet need for diagnostic and therapeutic biomarkers has fueled PD research for decades, but these efforts have not yet yielded actionable results. Recently, studies exploring mechanisms underlying PD progression have offered insights into multisystemic contributions to pathology, challenging the classic perspective of PD as a disease isolated to the brain. This shift in understanding has opened the door to potential new biomarkers from multiple sites in the body. This review focuses on emerging candidates for PD biomarkers in the context of current diagnostic approaches and multiple organ systems that contribute to disease.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Parkinson's disease
Clinical Biochemistry
Context (language use)
Disease
Review
Unmet needs
03 medical and health sciences
0302 clinical medicine
Drug Discovery
medicine
Animals
Humans
Intensive care medicine
Organ system
business.industry
Biochemistry (medical)
Advanced stage
Neurodegeneration
Disease progression
Parkinson Disease
medicine.disease
030104 developmental biology
Disease Progression
business
030217 neurology & neurosurgery
Biomarkers
Subjects
Details
- ISSN :
- 17520371
- Volume :
- 15
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Biomarkers in medicine
- Accession number :
- edsair.doi.dedup.....22b75404f6d7b9efd7a3c962ce072fff