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Predictive Value of Cerebrospinal Fluid Biomarkers for Tap Test Responsiveness in Patients With Suspected Idiopathic Normal Pressure Hydrocephalus
- Source :
- Frontiers in Aging Neuroscience, Vol 13 (2021), Frontiers in Aging Neuroscience
- Publication Year :
- 2021
- Publisher :
- Frontiers Media S.A., 2021.
-
Abstract
- Background: The value of cerebrospinal fluid (CSF) biomarkers for assessing idiopathic normal pressure hydrocephalus (iNPH) must be determined. This prospective study aimed to reveal the correlation between CSF biomarkers and clinical symptoms of iNPH and the predictive value of these biomarkers for tap test responsiveness.Methods: Thirty-nine patients with suspected iNPH were recruited, contributed qualified CSF, and underwent a tap test and unified pre- and post-test evaluations of the neurological function.Results: The analysis of biomarkers from the patients’ CSF showed decreased levels of tau and its phosphorylated form, especially in the tap test (+) group. The responsiveness of the tap test was also related to the number of combined symptoms (p < 0.01), and a correlation was found between the end pressure or pressure difference in CSF and tap test responsiveness (p < 0.05). The results of the binary logistic regression analysis showed that P (tap test responsiveness) = 1/1 + e∧ − (−5.505 + 55.314 * ratio of p/T-tau − 1.586 * numbers of combined symptoms). The combined indicators (−5.505 + 0.553 * percentage of p/T-tau − 1.586 * numbers of combined symptoms) resulted in the highest sensitivity and specificity of 94.12% and 72.73%, respectively.Conclusions: CSF biomarkers may be assessed to judge tap test responsiveness, which is beneficial for the feasibility of a clinical application.
- Subjects :
- 0301 basic medicine
Aging
medicine.medical_specialty
Cognitive Neuroscience
Neurosciences. Biological psychiatry. Neuropsychiatry
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Cerebrospinal fluid
Internal medicine
Medicine
In patient
Binary logistic regression analysis
tau
cerebrospinal fluid biomarkers
Prospective cohort study
Original Research
Aβ
Tap test
business.industry
Predictive value
030104 developmental biology
tap test
(Idiopathic) normal pressure hydrocephalus
Csf biomarkers
business
idiopathic normal pressure hydrocephalus
030217 neurology & neurosurgery
Neuroscience
RC321-571
Subjects
Details
- Language :
- English
- ISSN :
- 16634365
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Frontiers in Aging Neuroscience
- Accession number :
- edsair.doi.dedup.....22a99160b6e830d67c9cee5933481838
- Full Text :
- https://doi.org/10.3389/fnagi.2021.665878/full