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Application of the Convection–Dispersion Equation to Modelling Oral Drug Absorption
- Source :
- Bulletin of Mathematical Biology
- Publication Year :
- 2006
- Publisher :
- Springer-Verlag, 2006.
-
Abstract
- Models of systemic drug absorption after oral administration are frequently based on a direct or a delayed first-order rate process. In practice, the use of the first-order approach to predict drug concentrations in blood plasma frequently yields a considerable mismatch between predicted and measured concentration profiles. This is particularly true for the upswing of the plasma concentration after oral administration. The current investigation explores an alternative model to describe the absorption rate based on the convection–dispersion equation describing the transport of chemicals through the GI tract. This equation is governed by two parameters, transport velocity and dispersion coefficient. One solution of this equation for a specific set of initial and boundary conditions was used to model absorption of paracetamol in a 22-year-old man after oral administration. The GI-tract passage rate in this subject was influenced by co-administration of drugs that stimulate or delay gastric emptying. The transport-limited absorption function is more accurate in describing the plasma concentration versus time curve after oral administration than the first-order model. Additionally, it provides a mechanistic explanation for the observed curve through the differences in GI-tract passage rate.
- Subjects :
- Absorption (pharmacology)
Adult
Male
Mathematics(all)
Time Factors
Neuroscience(all)
General Mathematics
Immunology
Normal Distribution
Inverse Gaussian distribution
Administration, Oral
Gastric emptying
Pharmacology
Models, Biological
General Biochemistry, Genetics and Molecular Biology
Pharmacokinetics
Environmental Science(all)
Oral administration
Humans
Boundary value problem
NONMEM
General Environmental Science
Convection dispersion
Acetaminophen
Original Paper
Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
Chemistry
General Neuroscience
Mechanics
Analgesics, Non-Narcotic
Gastrointestinal Tract
Paracetamol
Computational Theory and Mathematics
Intestinal Absorption
General Agricultural and Biological Sciences
Oral retinoid
Subjects
Details
- Language :
- English
- ISSN :
- 15229602 and 00928240
- Volume :
- 69
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Bulletin of Mathematical Biology
- Accession number :
- edsair.doi.dedup.....228e6521b1d967c3de208fced08622da