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Metabolic responses of Eisenia fetida after sub-lethal exposure to organic contaminants with different toxic modes of action
- Source :
- Environmental pollution (Barking, Essex : 1987). 159(12)
- Publication Year :
- 2011
-
Abstract
- Nuclear magnetic resonance (NMR) – based metabolomics has the potential to identify toxic responses of contaminants within a mixture in contaminated soil. This study evaluated the metabolic response of Eisenia fetida after exposure to an array of organic compounds to determine whether contaminant-specific responses could be identified. The compounds investigated in contact tests included: two pesticides (carbaryl and chlorpyrifos), three pharmaceuticals (carbamazephine, estrone and caffeine), two persistent organohalogens (Aroclor 1254 and PBDE 209) and two industrial compounds (nonylphenol and dimethyl phthalate). Control and contaminant-exposed metabolic profiles were distinguished using principal component analysis and potential contaminant-specific biomarkers of exposure were found for several contaminants. These results suggest that NMR-based metabolomics offers considerable promise for differentiating between the different toxic modes of action (MOA) associated with sub-lethal toxicity to earthworms.
- Subjects :
- Eisenia fetida
Magnetic Resonance Spectroscopy
Health, Toxicology and Mutagenesis
010501 environmental sciences
Toxicology
01 natural sciences
03 medical and health sciences
chemistry.chemical_compound
Metabolomics
Carbaryl
Animals
Soil Pollutants
Oligochaeta
Organic Chemicals
030304 developmental biology
0105 earth and related environmental sciences
0303 health sciences
biology
General Medicine
Pesticide
biology.organism_classification
Pollution
3. Good health
Nonylphenol
chemistry
Chlorpyrifos
Environmental chemistry
Toxicity
Metabolome
Dimethyl phthalate
Subjects
Details
- ISSN :
- 18736424
- Volume :
- 159
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Environmental pollution (Barking, Essex : 1987)
- Accession number :
- edsair.doi.dedup.....228e59c6d4f4751e22e316f31cdd4199