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Transcriptomic Analysis Brings New Insight into the Biological Role of the Prion Protein during Mouse Embryogenesis
- Source :
- PLoS ONE, PLoS ONE, Public Library of Science, 2011, 6, online (8), Non paginé. ⟨10.1371/journal.pone.0023253⟩, PLoS ONE, Vol 6, Iss 8, p e23253 (2011), PLoS ONE, 2011, 6, online (8), Non paginé. ⟨10.1371/journal.pone.0023253⟩, Plos One 8 (6, online), Non paginé. (2011), PLoS ONE, Public Library of Science, 2011, 6, online (8), Non paginé. 〈10.1371/journal.pone.0023253〉
- Publication Year :
- 2011
- Publisher :
- Public Library of Science, 2011.
-
Abstract
- Chantier qualité GA; The biological function of the Prion protein remains largely unknown but recent data revealed its implication in early zebrafish and mammalian embryogenesis. To gain further insight into its biological function, comparative transcriptomic analysis between FVB/N and FVB/N Prnp knockout mice was performed at early embryonic stages. RNAseq analysis revealed the differential expression of 73 and 263 genes at E6.5 and E7.5, respectively. The related metabolic pathways identified in this analysis partially overlap with those described in PrP1 and PrP2 knockdown zebrafish embryos and prion-infected mammalian brains and emphasize a potentially important role for the PrP family genes in early developmental processes.
- Subjects :
- [SDV.SA]Life Sciences [q-bio]/Agricultural sciences
Embryology
Embryo, Nonmammalian
Mouse
animal diseases
Gene regulatory network
prion protein
prp
zebrafish
mammalian
embryogenesis
Transcriptomes
Prion Diseases
Transcriptome
Mice
0302 clinical medicine
Protein Isoforms
Gene Regulatory Networks
Zebrafish
Regulation of gene expression
Genetics
Mice, Knockout
0303 health sciences
Gene knockdown
[SDV.SA] Life Sciences [q-bio]/Agricultural sciences
Multidisciplinary
Reverse Transcriptase Polymerase Chain Reaction
Gene Expression Regulation, Developmental
Genomics
Animal Models
Immunohistochemistry
Infectious Diseases
Gene Knockdown Techniques
Knockout mouse
Medicine
Research Article
Histology
Prions
Science
Embryonic Development
Biology
PRNP
03 medical and health sciences
Model Organisms
Genome Analysis Tools
Animals
Gene Networks
030304 developmental biology
Gene Expression Profiling
Molecular Development
Zebrafish Proteins
biology.organism_classification
Embryo, Mammalian
Gene expression profiling
Gene Function
Genome Expression Analysis
Animal Genetics
030217 neurology & neurosurgery
Developmental Biology
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 6
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....228b8b4283291dc28029ca45cefb0b45