Back to Search Start Over

Immunotherapy with CD25/CD71-allodepleted T cells to improve T-cell reconstitution after matched unrelated donor hematopoietic stem cell transplant: a randomized trial

Authors :
Karl S. Peggs
Sarah J. Albon
Macarena Oporto Espuelas
Catherine Irving
Rachel Richardson
Joan Casanovas-Company
Rebecca Wallace
Aleks Guvenel
Sara Ghorashian
Angela Collura
Meera Subramaniyam
Barry Flutter
Bilyana Popova
Fernanda Castro
Andre Lopes
Kim Champion
Oliver Schofield
Laura Clifton-Hadley
Thomas Taylor
Maria Farrell
Stuart Adams
Kimberly C. Gilmour
Stephen Mackinnon
Eleni Tholouli
Persis J. Amrolia
Source :
Cytotherapy. 25:82-93
Publication Year :
2023
Publisher :
Elsevier BV, 2023.

Abstract

Delayed immune reconstitution is a major challenge after matched unrelated donor (MUD) stem cell transplant (SCT). In this randomized phase 2 multi-center trial, Adoptive Immunotherapy with CD25/71 allodepleted donor T cells to improve immunity after unrelated donor stem cell transplant (NCT01827579), the authors tested whether allodepleted donor T cells (ADTs) can safely be used to improve immune reconstitution after alemtuzumab-based MUD SCT for hematological malignancies.Patients received standard of care or up to three escalating doses of ADTs generated through CD25+/CD71+ immunomagnetic depletion. The primary endpoint of the study was circulating CD3+ T-cell count at 4 months post-SCT. Twenty-one patients were treated, 13 in the ADT arm and eight in the control arm.The authors observed a trend toward improved CD3+ T-cell count at 4 months in the ADT arm versus the control arm (230/µL versus 145/µL, P = 0.18), and three ADT patients achieved normal CD3+ T-cell count at 4 months (700/µL). The rates of significant graft-versus-host disease (GVHD) were comparable in both cohorts, with grade ≥2 acute GVHD in seven of 13 and four of eight patients and chronic GVHD in three of 13 and three of eight patients in the ADT and control arms, respectively.These data suggest that adoptive transfer of ADTs is safe, but that in the MUD setting the benefit in terms of T-cell reconstitution is limited. This approach may be of more use in the context of more rigorous T-cell depletion.

Details

ISSN :
14653249
Volume :
25
Database :
OpenAIRE
Journal :
Cytotherapy
Accession number :
edsair.doi.dedup.....22853e7e3a66fb0693366f4cdaa363f2
Full Text :
https://doi.org/10.1016/j.jcyt.2022.08.010