A double-blind comparison of nefopam and placebo used as a prernedication in children

Forty-two children received either nefopam or a matched placebo as oral premedication in a double-blind trial. Nefopam performed no better than placebo as a premedication and as postoperative analgesic. Its use is not recommended in paediatric anaesthesia because of a significantly high incidence of vomiting on awakening.