Back to Search
Start Over
A brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic-Raman nanoparticle
- Source :
- Nature medicine
- Publication Year :
- 2012
- Publisher :
- Springer Science and Business Media LLC, 2012.
-
Abstract
- The difficulty in delineating brain tumor margins is a major obstacle in the path toward better outcomes for patients with brain tumors. Current imaging methods are often limited by inadequate sensitivity, specificity and spatial resolution. Here we show that a unique triple-modality magnetic resonance imaging-photoacoustic imaging-Raman imaging nanoparticle (termed here MPR nanoparticle) can accurately help delineate the margins of brain tumors in living mice both preoperatively and intraoperatively. The MPRs were detected by all three modalities with at least a picomolar sensitivity both in vitro and in living mice. Intravenous injection of MPRs into glioblastoma-bearing mice led to MPR accumulation and retention by the tumors, with no MPR accumulation in the surrounding healthy tissue, allowing for a noninvasive tumor delineation using all three modalities through the intact skull. Raman imaging allowed for guidance of intraoperative tumor resection, and a histological correlation validated that Raman imaging was accurately delineating the brain tumor margins. This new triple-modality-nanoparticle approach has promise for enabling more accurate brain tumor imaging and resection.
- Subjects :
- Pathology
medicine.medical_specialty
Tumor resection
Brain tumor
Photoacoustic
Metal Nanoparticles
Photoacoustic imaging in biomedicine
02 engineering and technology
Spectrum Analysis, Raman
010402 general chemistry
01 natural sciences
Article
General Biochemistry, Genetics and Molecular Biology
surgery
Photoacoustic Techniques
Mice
medicine
cancer
Animals
Humans
Raman
multimodality
Modality (human–computer interaction)
medicine.diagnostic_test
SERS
Brain Neoplasms
business.industry
nanoparticle
Magnetic resonance imaging
tumor margin
General Medicine
contrast agent
gold
021001 nanoscience & nanotechnology
medicine.disease
Magnetic Resonance Imaging
Molecular Imaging
0104 chemical sciences
in vivo
silica
Radiology
Molecular imaging
0210 nano-technology
business
brain tumor
Histological correlation
MRI
Subjects
Details
- ISSN :
- 1546170X and 10788956
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Nature Medicine
- Accession number :
- edsair.doi.dedup.....22798b26dc72e79df49a413289e0225b