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Protective effect of ginseng polysaccharides on influenza viral infection

Authors :
Fu-Shi Quan
Jae-Min Song
Bao-Zhong Wang
Dae-Goon Yoo
Jae Joon Wee
Min-Kyung Park
Sang-Moo Kang
Min Chul Kim
Richard W. Compans
Kyoung-mi Park
Young-Keol Cho
Source :
PLoS ONE, Vol 7, Iss 3, p e33678 (2012), PLoS ONE
Publication Year :
2012
Publisher :
Public Library of Science (PLoS), 2012.

Abstract

Ginseng polysaccharide has been known to have multiple immunomodulatory effects. In this study, we investigated whether Panax ginseng polysaccharide (GP) would have a preventive effect on influenza infection. Administration of mice with GP prior to infection was found to confer a survival benefit against infection with H1N1 (A/PR/8/34) and H3N2 (A/Philippines/82) influenza viruses. Mice infected with the 2009 H1N1 virus suspended in GP solution showed moderately enhanced survival rates and lower levels of lung viral titers and the inflammatory cytokine (IL-6). Daily treatment of vaccinated mice with GP improved their survival against heterosubtypic lethal challenge. This study demonstrates the first evidence that GP can be used as a remedy against influenza viral infection.

Details

Language :
English
ISSN :
19326203
Volume :
7
Issue :
3
Database :
OpenAIRE
Journal :
PLoS ONE
Accession number :
edsair.doi.dedup.....22738684e0428b42323efb4160ede103