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Protein synthesis inhibitors attenuate seizures induced in rats by lithium plus pilocarpine
- Source :
- Experimental neurology. 129(1)
- Publication Year :
- 1994
-
Abstract
- The effects of two protein synthesis inhibitors, cycloheximide and anisomycin, were tested on seizures induced by coadministration of lithium and pilocarpine to rats. Systemic cycloheximide (2 mg/kg, s.c.) and centrally administered anisomycin (300 micrograms/10 microliters, i.c.v.) doubled the latency to initiation of seizures and to status epilepticus, while peripherally administered anisomycin (50 mg/kg, s.c.) completely blocked lithium-pilocarpine seizures. These results indicate that protein synthesis is required for initiation of seizures.
- Subjects :
- Male
Time Factors
Lithium (medication)
Injections, Subcutaneous
Status epilepticus
Cycloheximide
Pharmacology
Hippocampus
Cerebral Ventricles
Rats, Sprague-Dawley
chemistry.chemical_compound
Status Epilepticus
Developmental Neuroscience
Seizures
medicine
Protein biosynthesis
Animals
Anisomycin
Injections, Intraventricular
Protein Synthesis Inhibitors
Protein synthesis inhibitor
Pilocarpine
Electroencephalography
Rats
Sprague dawley
Neurology
chemistry
medicine.symptom
Lithium Chloride
medicine.drug
Subjects
Details
- ISSN :
- 00144886
- Volume :
- 129
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Experimental neurology
- Accession number :
- edsair.doi.dedup.....226ae7c3d82008e67b4e24bc33f83734