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Hyperammonemia crisis following parturition in a female patient with ornithine transcarbamylase deficiency
- Source :
- World Journal of Hepatology
- Publication Year :
- 2017
- Publisher :
- Baishideng Publishing Group Inc., 2017.
-
Abstract
- Ornithine transcarbamylase deficiency (OTCD) is an X-linked disorder, with an estimated prevalence of 1 per 80000 live births. Female patients with OTCD develop metabolic crises that are easily provoked by non-predictable common disorders, such as genetic (private mutations and lyonization) and external factors; however, the outcomes of these conditions may differ. We resuscitated a female patient with OTCD from hyperammonemic crisis after she gave birth. Hyperammonemia after parturition in a female patient with OTCD can be fatal, and this type of hyperammonemia persists for an extended period of time. Here, we describe the cause and treatment of hyperammonemia in a female patient with OTCD after parturition. Once hyperammonemia crisis occurs after giving birth, it is difficult to improve the metabolic state. Therefore, it is important to perform an early intervention before hyperammonemia occurs in patients with OTCD or in carriers after parturition.
- Subjects :
- 0301 basic medicine
Metabolic state
Pediatrics
medicine.medical_specialty
Brain image
Glutamine
Case Report
Urea cycle disorders
03 medical and health sciences
0302 clinical medicine
Internal medicine
Female patient
Ornithine transcarbamylase deficiency
medicine
Hyperammonemia
In patient
Hepatology
business.industry
Uterus
medicine.disease
Amino acid
Metabolic crises
030104 developmental biology
Endocrinology
business
Delivery
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 19485182
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- World Journal of Hepatology
- Accession number :
- edsair.doi.dedup.....226262c7dfd8e3c9cd417bd12aa8a2e6