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ESPGHAN Committee on Nutrition Position Paper. Intravenous Lipid Emulsions and Risk of Hepatotoxicity in Infants and Children
- Source :
- Journal of Pediatric Gastroenterology and Nutrition, 62(5), 776-792. Lippincott Williams & Wilkins, Journal of Pediatric Gastroenterology and Nutrition, 62(5), 776-792. Lippincott Williams and Wilkins, Hojsak, I, Colomb, V, Braegger, C, Bronsky, J, Campoy, C, Domellof, M, Embleton, N, Mis, N F, Hulst, J M, Indrio, F, Lapillonne, A, Mihatsch, W, Molgaard, C, van Goudoever, J & Fewtrell, M 2016, ' ESPGHAN Committee on Nutrition Position Paper. Intravenous Lipid Emulsions and Risk of Hepatotoxicity in Infants and Children: a Systematic Review and Meta-analysis ', Journal of Pediatric Gastroenterology and Nutrition, vol. 62, no. 5, pp. 776-792 . https://doi.org/10.1097/MPG.0000000000001121
- Publication Year :
- 2016
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2016.
-
Abstract
- The aim of the present article was to perform a systematic review with meta-analysis of available scientific evidence regarding the role of different intravenous lipid emulsions (ILE) in the pathogenesis of cholestasis and parenteral nutrition-associated liver disease. A systematic review of the literature (up to March 2015) identified 23 randomized controlled trials (RCTs). Of these, 17 were performed in preterm infants or critically ill neonates with a short duration of intervention, 2 in older children with short-term use (following surgery or bone marrow transplantation), 1 in neonates with long-term use, and 3 in infants and children receiving long-term parenteral nutrition (PN). Meta-analysis showed no differences in the rate of cholestasis or bilirubin levels associated with short-term use of different ILEs. Because of high heterogeneity of the long-term studies no meta-analysis could be performed. Available studies found that the use of multicomponent fish oil (FO)-containing ILE compared with pure soya bean oil (SO), ILE-reduced liver enzymes, and bilirubin levels in noncholestatic children on long-term PN and one other RCT found that FO-based ILE-reversed cholestasis in a proportion of patients. The ESPGHAN Committee on Nutrition concludes that there is no evidence of a difference in rates of cholestasis or bilirubin levels between different ILE for short-term use in neonates. The use of multicomponent FO-containing ILE may contribute to a decrease in total bilirubin levels in children with IF on prolonged PN. Well-designed RCTs are, however, lacking and long-term effects have not been determined.
- Subjects :
- Male
0301 basic medicine
Fat Emulsions, Intravenous
Parenteral Nutrition
Pediatrics
medicine.medical_specialty
Advisory Committees
610 Medicine & health
Risk Assessment
law.invention
03 medical and health sciences
Liver disease
0302 clinical medicine
Liver Function Tests
Randomized controlled trial
Cholestasis
law
Humans
Medicine
2715 Gastroenterology
Intravenous Lipid Emulsions
2735 Pediatrics, Perinatology and Child Health
Food science
Child
Randomized Controlled Trials as Topic
030109 nutrition & dietetics
medicine.diagnostic_test
business.industry
Infant, Newborn
Gastroenterology
Infant
medicine.disease
Fish oil
Europe
Treatment Outcome
Parenteral nutrition
10036 Medical Clinic
Child, Preschool
Meta-analysis
Pediatrics, Perinatology and Child Health
Female
030211 gastroenterology & hepatology
business
Risk assessment
Liver function tests
Subjects
Details
- ISSN :
- 02772116
- Volume :
- 62
- Database :
- OpenAIRE
- Journal :
- Journal of Pediatric Gastroenterology & Nutrition
- Accession number :
- edsair.doi.dedup.....22620bd55745cfe4ffccb24f585a1458