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Transient bullous dermolysis of the newborn. Retention of anchoring fibril- and basal lamina-like structures in keratinocytes and evidence of collagenolysis
- Source :
- Journal of Cutaneous Pathology. 19:496-501
- Publication Year :
- 1992
- Publisher :
- Wiley, 1992.
-
Abstract
- In a freshly induced blister from transient bullous dermolysis of the newborn, we found in epidermal basal cells structures similar to anchoring fibrils and lamina densa, often in combination. In the upper dermis, collagenolysis and phagocytosis of degenerated collagen fragments were observed. It is concluded that the stellate inclusions previously reported in this disease are prematurely assembled anchoring fibrils and lamina densa. A disturbance of delivery mechanism of precursor materials for anchoring fibrils and lamina densa may cause the deficiency of these structures which are essential for the integrity of dermo-epidermal adhesion. The presence of many normal anchoring fibrils and lamina densa in perilesional skin and their prompt degeneration after rupture of the inclusions previously led us to conclude that lytic enzymes are involved in the formation of blisters in this disease. The new finding of collagen phagocytosis in the lesional dermis seemed to support this contention.
- Subjects :
- Keratinocytes
Male
Pathology
medicine.medical_specialty
Time Factors
Histology
Biopsy
Transient bullous dermolysis of the newborn
Dermatology
Biology
Fibril
Pathology and Forensic Medicine
Dermis
Anchoring fibrils
medicine
Humans
Skin
Basement membrane
Skin Diseases, Vesiculobullous
integumentary system
urogenital system
Infant, Newborn
medicine.disease
Microscopy, Electron
medicine.anatomical_structure
Lamina densa
Basal lamina
Collagen
Keratinocyte
Subjects
Details
- ISSN :
- 16000560 and 03036987
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Journal of Cutaneous Pathology
- Accession number :
- edsair.doi.dedup.....22525071ee2a8ff0993cc0d557e71582