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Co-exposure with fullerene may strengthen health effects of organic industrial chemicals
- Source :
- PLoS ONE, Vol 9, Iss 12, p e114490 (2014), Lehto, M, Karilainen, T, Rog, T, Cramariuc, O, Vanhala, E, Tornaeus, J, Taberman, H, Janis, J, Alenius, H, Vattulainen, I & Laine, O 2014, ' Co-Exposure with Fullerene May Strengthen Health Effects of Organic Industrial Chemicals ', P L o S One, vol. 9, no. 12, pp. 24 . https://doi.org/10.1371/journal.pone.0114490, PLoS ONE
- Publication Year :
- 2014
- Publisher :
- Public Library of Science (PLoS), 2014.
-
Abstract
- In vitro toxicological studies together with atomistic molecular dynamics simulations show that occupational co-exposure with C-60 fullerene may strengthen the health effects of organic industrial chemicals. The chemicals studied are acetophenone, benzaldehyde, benzyl alcohol, m-cresol, and toluene which can be used with fullerene as reagents or solvents in industrial processes. Potential co-exposure scenarios include a fullerene dust and organic chemical vapor, or a fullerene solution aerosolized in workplace air. Unfiltered and filtered mixtures of C-60 and organic chemicals represent different co-exposure scenarios in in vitro studies where acute cytotoxicity and immunotoxicity of C-60 and organic chemicals are tested together and alone by using human THP-1-derived macrophages. Statistically significant co-effects are observed for an unfiltered mixture of benzaldehyde and C-60 that is more cytotoxic than benzaldehyde alone, and for a filtered mixture of m-cresol and C-60 that is slightly less cytotoxic than m-cresol. Hydrophobicity of chemicals correlates with co-effects when secretion of pro-inflammatory cytokines IL-1 beta and TNF-alpha is considered. Complementary atomistic molecular dynamics simulations reveal that C-60 co-aggregates with all chemicals in aqueous environment. Stable aggregates have a fullerene-rich core and a chemical-rich surface layer, and while essentially all C-60 molecules aggregate together, a portion of organic molecules remains in water.
- Subjects :
- Light
Cytotoxicity
Interleukin-1beta
lcsh:Medicine
02 engineering and technology
010501 environmental sciences
Toxicology
Molecular Dynamics
01 natural sciences
Mass Spectrometry
POLYCYCLIC AROMATIC-HYDROCARBONS IN-VITRO EVALUATION MOLECULAR-DYNAMICS AQUEOUS SUSPENSIONS C-60 TOXICITY NANOPARTICLES EXPOSURE DISTRIBUTIONS DISPERSIONS
Analytical Chemistry
Scattering
chemistry.chemical_compound
Cresols
Computational Chemistry
Immunotoxicology
Organic chemistry
Nanotechnology
Drug Interactions
Electron Microscopy
lcsh:Science
Microscopy
Multidisciplinary
Aqueous solution
Organic Compounds
Physics
Electromagnetic Radiation
Electrospray Ionization Mass Spectrometry
021001 nanoscience & nanotechnology
3. Good health
Chemistry
Benzyl alcohol
Benzaldehydes
Physical Sciences
Thermodynamics
Engineering and Technology
Fullerenes
0210 nano-technology
Hydrophobic and Hydrophilic Interactions
Acetophenone
Research Article
Fullerene
Liquid Chromatography-Mass Spectrometry
Air Pollutants, Occupational
Molecular Dynamics Simulation
Research and Analysis Methods
Benzaldehyde
Cell Line, Tumor
Humans
0105 earth and related environmental sciences
Nanomaterials
business.industry
Tumor Necrosis Factor-alpha
Macrophages
Organic Chemistry
lcsh:R
Chemical Compounds
Light Scattering
Acetophenones
Biology and Life Sciences
Chemical industry
Toluene
chemistry
13. Climate action
Reagent
Nanoparticles
Transmission Electron Microscopy
lcsh:Q
business
Benzyl Alcohol
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 9
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....224a0b776429d0d38f087fa4a49325fb