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BMI at Age 17 Years and Diabetes Mortality in Midlife: A Nationwide Cohort of 2.3 Million Adolescents
- Source :
- Diabetes Care. 39:1996-2003
- Publication Year :
- 2016
- Publisher :
- American Diabetes Association, 2016.
-
Abstract
- OBJECTIVE The sequelae of increasing childhood obesity are of major concern. We assessed the association of BMI in late adolescence with diabetes mortality in midlife. RESEARCH DESIGN AND METHODS The BMI values of 2,294,139 Israeli adolescents (age 17.4 ± 0.3 years), measured between 1967 and 2010, were grouped by U.S. Centers for Disease Control and Prevention age/sex percentiles and by ordinary BMI values. The outcome, obtained by linkage with official national records, was death attributed to diabetes mellitus (DM) as the underlying cause. Cox proportional hazards models were applied. RESULTS During 42,297,007 person-years of follow-up (median, 18.4 years; range CONCLUSIONS Adolescent BMI, including values within the currently accepted “normal” range, strongly predicts DM mortality up to the seventh decade. The increasing prevalence of childhood and adolescent overweight and obesity points to a substantially increased future adult DM burden.
- Subjects :
- Adult
Male
Pediatric Obesity
Pediatrics
medicine.medical_specialty
Adolescent
Endocrinology, Diabetes and Metabolism
030209 endocrinology & metabolism
Overweight
Childhood obesity
Body Mass Index
Young Adult
03 medical and health sciences
0302 clinical medicine
Diabetes Mellitus
Prevalence
Internal Medicine
medicine
Humans
Prospective Studies
030212 general & internal medicine
Israel
Young adult
Proportional Hazards Models
Advanced and Specialized Nursing
business.industry
Proportional hazards model
Hazard ratio
Middle Aged
medicine.disease
Obesity
Cohort
Female
medicine.symptom
business
Body mass index
Follow-Up Studies
Subjects
Details
- ISSN :
- 19355548 and 01495992
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- Diabetes Care
- Accession number :
- edsair.doi.dedup.....2246f65c5e5648d7dc4142a314b1af24