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The Absence of Transthyretin does not Impair Regulation of Lipid and Glucose Metabolism
- Source :
- Repositório Científico de Acesso Aberto de Portugal, Repositório Científico de Acesso Aberto de Portugal (RCAAP), instacron:RCAAP
- Publication Year :
- 2007
- Publisher :
- Georg Thieme Verlag KG, 2007.
-
Abstract
- Increased levels of neuropeptide Y have been reported in transthyretin-null mice. This effect might be related to transthyretin ligands (retinol and thyroxine) since, through binding to nuclear receptors, they modulate the expression of genes that control cellular metabolism. The retinoic X receptors form obligatory heterodimers with peroxisome proliferator-activated receptors and liver X receptors - potent regulators of fat, glucose and cholesterol homeostasis. We used transthyretin-null mice to investigate whether the absence of transthyretin influences metabolism. Transthyretin-null mice do not differ from controls in body weight and white adipose tissue morphology, nor in basal or fast-induced circulating levels of glucose, lipids, and leptin. Glucose tolerance tests show that transthyretin-null mice have normal capacity to remove and metabolize energy substrates. Expression of genes encoding lipid transporters and nuclear receptors are also similar in transthyretin-null and control mice. Therefore, the absence of transthyretin does not seem to influence the regulation of lipid and glucose metabolism.<br />POCTI / NSE / 37315 / 2001 and POCI/SAU-NEU/56618/2004, FEDER from Fundação para a Ciência e Tecnologia (Portugal)
- Subjects :
- Blood Glucose
Endocrinology, Diabetes and Metabolism
Medicina Básica [Ciências Médicas]
Clinical Biochemistry
Peroxisome proliferator-activated receptor
White adipose tissue
Transthyretin
PPAR
Biochemistry
Mice
0302 clinical medicine
Endocrinology
Adipocytes
Prealbumin
Receptor
chemistry.chemical_classification
0303 health sciences
Fasting
General Medicine
Neuropeptide Y receptor
Lipids
3. Good health
Ciências Médicas::Medicina Básica
LXR
medicine.medical_specialty
RXR
030209 endocrinology & metabolism
macromolecular substances
Biology
Carbohydrate metabolism
Retinoids
03 medical and health sciences
Internal medicine
medicine
Animals
RNA, Messenger
Liver X receptor
030304 developmental biology
Science & Technology
Body Weight
Biochemistry (medical)
nutritional and metabolic diseases
Glucose Tolerance Test
Lipid Metabolism
nervous system diseases
Thyroxine
Glucose
Gene Expression Regulation
Nuclear receptor
chemistry
biology.protein
Subjects
Details
- ISSN :
- 14394286 and 00185043
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- Hormone and Metabolic Research
- Accession number :
- edsair.doi.dedup.....2235fef9b38b5f55e76c10b83fb1a9b4