Modulatory impact of cardiac rehabilitation on hyperhomocysteinemia in patients with coronary artery disease and 'normal' lipid levels

Despite these limitations, this study suggests that cardiac rehabilitation and exercise training may significantly reduce homocysteine levels in normolipidemic patients with CAD and hyperhomocysteinemia. This 12% reduction in homocysteine levels noted in our study would be expected to produce 20% to 30% reductions in CAD risk. Further larger studies are needed to confirm our findings on the additional beneficial effect of exercise training in patients with CAD.