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Multi-molecule reaction of serum albumin can occur through thiol-yne coupling
- Publication Year :
- 2016
-
Abstract
- The free-radical hydrothiolation of alkynes (thiol-yne coupling, TYC) unites two thiol fragments across the carbon-carbon triple bond to give a dithioether derivative with exclusive 1,2-addition; this reaction can be used for modification of peptides and proteins allowing glycoconjugation and fluorescent labeling. These results have implications not only as a flexible strategy for attaching two modifications at a single site in proteins but also for unanticipated side-reactions of reagents (such as cycloalkynes) used in other protein coupling reactions.
- Subjects :
- Models, Molecular
Stereochemistry
Protein Conformation
Serum albumin
Catalysis
Coupling reaction
chemistry.chemical_compound
Protein structure
Materials Chemistry
Molecule
Animals
Sulfhydryl Compounds
chemistry.chemical_classification
biology
Chemistry
Metals and Alloys
Serum Albumin, Bovine
General Chemistry
Triple bond
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Reagent
Alkynes
Ceramics and Composites
Thiol
biology.protein
Cattle
Derivative (chemistry)
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....2216d462bb0af817c9a53738c882fccd