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Genes
- Source :
- Genes, Volume 8, Issue 2, Genes, Vol 8, Iss 2, p 50 (2017)
- Publication Year :
- 2017
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2017.
-
Abstract
- Small regulatory RNAs (sRNAs) of Shigella dysenteriae and other pathogens are vital for the regulation of virulence-associated genes and processes. Here, we characterize RyfA1, one member of a sibling pair of sRNAs produced by S. dysenteriae. Unlike its nearly identical sibling molecule, RyfA2, predicted to be encoded almost exclusively by non-pathogenic species, the presence of a gene encoding RyfA1, or a RyfA1-like molecule, is strongly correlated with virulence in a variety of enteropathogens. In S. dysenteriae, the overproduction of RyfA1 negatively impacts the virulence-associated process of cell-to-cell spread as well as the expression of ompC, a gene encoding a major outer membrane protein important for the pathogenesis of Shigella. Interestingly, the production of RyfA1 is controlled by a second sRNA, here termed RyfB1, the first incidence of one regulatory small RNA controlling another in S. dysenteriae or any Shigella species. Published version
- Subjects :
- 0301 basic medicine
Small RNA
Shigella dysenteriae
riboregulators
lcsh:QH426-470
030106 microbiology
Virulence
Shigella
Biology
medicine.disease_cause
Article
Microbiology
03 medical and health sciences
Genetics
medicine
sibling
Overproduction
Gene
Genetics (clinical)
pathogenesis
biology.organism_classification
OmpC
lcsh:Genetics
030104 developmental biology
Transfer RNA
Bacterial outer membrane
sRNA
Subjects
Details
- Language :
- English
- ISSN :
- 20734425
- Database :
- OpenAIRE
- Journal :
- Genes
- Accession number :
- edsair.doi.dedup.....220eab1570be9efc1ed7ed2a2b11dd6f
- Full Text :
- https://doi.org/10.3390/genes8020050