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Sensitivity and specificity of various markers of inflammation for the prediction of tumor necrosis factor-α and interleukin-6 in patients with sepsis
- Source :
- Critical Care Medicine. 27:1814-1818
- Publication Year :
- 1999
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 1999.
-
Abstract
- Objectives To determine correlations and predictive strength of surrogate markers (body temperature, leukocyte count, C-reactive protein [CRP], and procalcitonin [PCT]) with elevated levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in septic patients. Design Prospective consecutive case series. Setting Surgical intensive care unit (ICU) of a university hospital. Patients A total of 175 patients experiencing intensive care unit stays >48 hrs categorized for sepsis according to ACCP/ SCCM Consensus Conference criteria. Measurements and main results CRP and PCT were both significantly correlated with TNF-alpha and IL-6. Based on the area-under-the-curve of the receiver operating characteristics curves, predicting capability was highest for PCT (0.814 for TNF-alpha >40 pg/mL and 0.794 for IL-6 >500 pg/mL), moderate with CRP (0.732 and 0.716, respectively), and lowest for leukocyte count (0.493 and 0.483, respectively) and body temperature (0.587 and 0.589, respectively). Sensitivity, specificity, positive, and negative predictive values and test effectiveness all followed this same pattern of being highest for PCT followed by CRP, with leukocyte count and body temperature being lowest. Conclusion PCT may be an early and better marker of elevated cytokines than the more classic criteria of inflammation.
- Subjects :
- Adult
Calcitonin
Male
medicine.medical_specialty
Adolescent
Calcitonin Gene-Related Peptide
Critical Care and Intensive Care Medicine
Sensitivity and Specificity
Gastroenterology
Procalcitonin
Body Temperature
law.invention
Sepsis
Leukocyte Count
law
Intensive care
Internal medicine
medicine
Humans
Prospective Studies
Protein Precursors
Interleukin 6
Prospective cohort study
Aged
Glycoproteins
Aged, 80 and over
biology
Receiver operating characteristic
Interleukin-6
Tumor Necrosis Factor-alpha
business.industry
Consecutive case series
Middle Aged
medicine.disease
Intensive care unit
C-Reactive Protein
Immunology
biology.protein
Female
business
Biomarkers
Subjects
Details
- ISSN :
- 00903493
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Critical Care Medicine
- Accession number :
- edsair.doi.dedup.....220d7fafd5bba866f77fb03e69c81df7