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Determinants of myocardial function characterized by CMR-derived strain parameters in left ventricular non-compaction cardiomyopathy
- Source :
- Scientific Reports, Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019), Scientific Reports, 9 (1)
- Publication Year :
- 2019
- Publisher :
- ETH Zurich, 2019.
-
Abstract
- Clinical presentation of left ventricular non-compaction cardiomyopathy (LVNC) can be heterogeneous from asymptomatic expression to congestive heart failure. Deformation indices assessed by cardiovascular magnetic resonance (CMR) can determine subclinical alterations of myocardial function and have been reported to be more sensitive to functional changes than ejection fraction. The objective of the present study was to investigate the determinants of myocardial deformation indices in patients with LVNC. Twenty patients with LVNC (44.7 ± 14.0 years) and twenty age- and gender-matched controls (49.1 ± 12.4 years) underwent functional CMR imaging using an ECG-triggered steady state-free-precession sequence (SSFP). Deformation indices derived with a feature tracking algorithm were calculated including end-systolic global longitudinal strain (GLS), circumferential strain (GCS), longitudinal and circumferential strain rate (SRll and SRcc). Twist and rotation were determined using an in-house developed post-processing pipeline. Global deformation indices (GLS, GCS, SRll and SRcc) were significantly lower in patients with LVNC compared to healthy controls (all, p<br />Scientific Reports, 9 (1)<br />ISSN:2045-2322
- Subjects :
- Adult
Male
medicine.medical_specialty
Rotation
Heart Ventricles
Cardiomyopathy
lcsh:Medicine
Magnetic Resonance Imaging, Cine
610 Medicine & health
Heart failure
030204 cardiovascular system & hematology
Asymptomatic
Ventricular Function, Left
Article
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Internal medicine
Image Interpretation, Computer-Assisted
medicine
Humans
Prospective Studies
lcsh:Science
Prospective cohort study
1000 Multidisciplinary
Multidisciplinary
Ejection fraction
medicine.diagnostic_test
10042 Clinic for Diagnostic and Interventional Radiology
business.industry
lcsh:R
Magnetic resonance imaging
Steady-state free precession imaging
Strain rate
Middle Aged
medicine.disease
Echocardiography
Case-Control Studies
10209 Clinic for Cardiology
Cardiology
lcsh:Q
Female
medicine.symptom
business
Cardiomyopathies
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Database :
- OpenAIRE
- Journal :
- Scientific Reports, Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019), Scientific Reports, 9 (1)
- Accession number :
- edsair.doi.dedup.....22081c24dd82d6cc3b7c21fb09a382d3
- Full Text :
- https://doi.org/10.3929/ethz-b-000376550