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High-strength, porous additively manufactured implants with optimized mechanical osseointegration
- Source :
- Biomaterials. 279:121206
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Optimization of porous titanium alloy scaffolds designed for orthopedic implants requires balancing mechanical properties and osseointegrative performance. The tradeoff between scaffold porosity and the stiffness/strength must be optimized towards the goal to improve long term load sharing while simultaneously promoting osseointegration . Osseointegration into porous titanium implants covering a wide range of porosity (0%–90%) and manufactured by laser powder bed fusion (LPBF) was evaluated with an established ovine cortical and cancellous defect model. Direct apposition and remodeling of woven bone was observed at the implant surface , as well as bone formation within the interstices of the pores. A linear relationship was observed between the porosity and benchtop mechanical properties of the scaffolds, while a non-linear relationship was observed between porosity and the ex vivo cortical bone-implant interfacial shear strength . Our study supports the hypothesis of porosity dependent performance tradeoffs, and establishes generalized relationships between porosity and performance for design of topological optimized implants for osseointegration. These results are widely applicable for orthopedic implant design for arthroplasty components, arthrodesis devices such as spinal interbody fusion implants, and patient matched implants for treatment of large bone defects.
- Subjects :
- Scaffold
Materials science
Biophysics
chemistry.chemical_element
Bioengineering
Osseointegration
Biomaterials
Alloys
medicine
Animals
Humans
Orthopedic implant
Porosity
Titanium
Sheep
Stiffness
Prostheses and Implants
Interfacial shear
Linear relationship
chemistry
Mechanics of Materials
Ceramics and Composites
medicine.symptom
Biomedical engineering
Subjects
Details
- ISSN :
- 01429612
- Volume :
- 279
- Database :
- OpenAIRE
- Journal :
- Biomaterials
- Accession number :
- edsair.doi.dedup.....21ffb81a9cb8ab471359f2d6838c9db2