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KCNJ5 Somatic Mutation Is a Predictor of Hypertension Remission After Adrenalectomy for Unilateral Primary Aldosteronism
- Source :
- The Journal of clinical endocrinology and metabolism. 104(10)
- Publication Year :
- 2019
-
Abstract
- ContextPrimary aldosteronism (PA) is the most common cause of endocrine hypertension (HT). HT remission (defined as blood pressure ObjectiveTo determine clinical and molecular features associated with HT remission after adrenalectomy in patients with unilateral PA.MethodsWe retrospectively evaluated 100 patients with PA (60 women; median age at diagnosis 48 years with a median follow-up of 26 months). Anatomopathological analysis revealed 90 aldosterone-producing adenomas, 1 carcinoma, and 9 unilateral adrenal hyperplasias. All patients had biochemical cure after unilateral adrenalectomy. KCNJ5 gene was sequenced in 76 cases.ResultsKCNJ5 mutations were identified in 33 of 76 (43.4%) tumors: p.Gly151Arg (n = 17), p.Leu168Arg (n = 15), and p.Glu145Gln (n = 1). HT remission was reported in 37 of 100 (37%) patients. Among patients with HT remission, 73% were women (P = 0.04), 48.6% used more than three antihypertensive medications (P = 0.0001), and 64.9% had HT duration ConclusionThe presence of a KCNJ5 somatic mutation is an independent predictor of HT remission after unilateral adrenalectomy in patients with unilateral PA.
- Subjects :
- Adult
Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Clinical Biochemistry
030209 endocrinology & metabolism
Context (language use)
030204 cardiovascular system & hematology
Biochemistry
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Endocrinology
Germline mutation
Primary aldosteronism
Internal medicine
KCNJ5
Hyperaldosteronism
medicine
Carcinoma
Humans
Retrospective Studies
biology
business.industry
Adrenalectomy
Biochemistry (medical)
Remission Induction
Retrospective cohort study
Middle Aged
medicine.disease
Prognosis
Adrenal Cortex Neoplasms
Blood pressure
G Protein-Coupled Inwardly-Rectifying Potassium Channels
Adrenocortical Adenoma
Hypertension
Mutation
biology.protein
Female
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 19457197
- Volume :
- 104
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- The Journal of clinical endocrinology and metabolism
- Accession number :
- edsair.doi.dedup.....21fe00d83a35cb2e28c940c763a69038