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Drug-induced bile duct injury
- Source :
- Biochimica et biophysica acta. Molecular basis of disease. 1864(4 Pt)
- Publication Year :
- 2017
-
Abstract
- Drug-induced liver injury includes a spectrum of pathologies, some related to the mode of injury, some to the cell type primarily damaged. Among these, drug-induced bile duct injury is characterized by the destruction of the biliary epithelium following exposure to a drug. Most of the drugs associated with bile duct injury cause immune-mediated lesions to the epithelium of interlobular ducts. These share common histopathological features with primary biliary cholangitis, such as inflammation and necrosis at the expense of cholangiocytes and, if the insult persists, bile duct loss and biliary cirrhosis. Some drugs selectively target larger ducts. Such injury is often dose-dependent and thought to be the result of intrinsic drug toxicity. The histological changes resemble those seen in primary sclerosing cholangitis. This overview focuses on the clinical and pathological features of bile duct injury associated with drug treatment and on the immunological and biochemical effects that drugs exert on the biliary epithelium. This article is part of a Special Issue entitled: Cholangiocytes in Health and Disease edited by Jesus Banales, Marco Marzioni, Nicholas LaRusso and Peter Jansen.
- Subjects :
- Pathology
medicine.medical_specialty
Cholagogues and Choleretics
Necrosis
Biliary cirrhosis
Cholangitis, Sclerosing
Amoxicillin-Potassium Clavulanate Combination
Cholangiocyte
Primary sclerosing cholangitis
Bile Acids and Salts
03 medical and health sciences
0302 clinical medicine
medicine
Humans
Molecular Biology
Biotransformation
Liver injury
Cholestasis
business.industry
Bile duct
Vanishing bile duct syndrome
Epithelial Cells
medicine.disease
Epithelium
3. Good health
medicine.anatomical_structure
Carbamazepine
Liver
030220 oncology & carcinogenesis
Molecular Medicine
030211 gastroenterology & hepatology
Bile Ducts
medicine.symptom
Chemical and Drug Induced Liver Injury
business
Biomarkers
Subjects
Details
- ISSN :
- 09254439
- Volume :
- 1864
- Issue :
- 4 Pt
- Database :
- OpenAIRE
- Journal :
- Biochimica et biophysica acta. Molecular basis of disease
- Accession number :
- edsair.doi.dedup.....21fb31e725781b5d5160b89941ed73bc